Deciphering the quorum-sensing lexicon of the gut microbiota

Oliveira, Rita Almeida; Cabral, Vitor; Torcato, Inês M.; Xavier, Karina B.

doi:10.1016/j.chom.2023.03.015

Cited by 11 publications

(9 citation statements)

References 102 publications

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“…1A). pMMCAT also harbors an Mfa-like short adhesive fimbriae locus, with an adjacent LuxR-like transcriptional regulator, which often respond to quorum sensing auto-inducers or other small molecules 33 . In biofilms, fimbriae are important for cell surface attachment as well as cell-cell adhesion 34 .…”

Section: Resultsmentioning

confidence: 99%

A pervasive large conjugative plasmid mediates multispecies biofilm formation in the intestinal microbiota increasing resilience to perturbations

García-Bayona,

Said,

Coyne

et al. 2024

Preprint

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Although horizontal gene transfer is pervasive in the intestinal microbiota, we understand only superficially the roles of most exchanged genes and how the mobile repertoire affects community dynamics. Similarly, little is known about the mechanisms underlying the ability of a community to recover after a perturbation. Here, we identified and functionally characterized a large conjugative plasmid that is one of the most frequently transferred elements among Bacteroidales species and is ubiquitous in diverse human populations. This plasmid encodes both an extracellular polysaccharide and fimbriae, which promote the formation of multispecies biofilms in the mammalian gut. We use a hybridization-based approach to visualize biofilms in clarified whole colon tissue with unprecedented 3D spatial resolution. These biofilms increase bacterial survival to common stressors encountered in the gut, increasing strain resiliency, and providing a rationale for the plasmid's recent spread and high worldwide prevalence.

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Section: Resultsmentioning

confidence: 99%

A pervasive large conjugative plasmid mediates multispecies biofilm formation in the intestinal microbiota increasing resilience to perturbations

García-Bayona,

Said,

Coyne

et al. 2024

Preprint

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“…Priority effects can occur through inhibitory interactions like interbacterial antagonism, which allows established strains to kill new arrivals 57,76 (Fig. 5e), or through facilitative interactions like quorum sensing 77 , cross-feeding 78 , and the production of public goods 79 . Regardless of their mechanism, strong collective effects in the gut microbiome complicate the design of microbiome therapeutics by creating historical contingency in colonization outcomes (Fig.…”

Section: Discussionmentioning

confidence: 99%

Prolonged delays in human microbiota transmission after a controlled antibiotic perturbation

Xue,

Walton,

Goldman

et al. 2023

Preprint

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Humans constantly encounter new microbes, but few become long-term residents of the adult gut microbiome. Classical theories predict that colonization is determined by the availability of open niches, but it remains unclear whether other ecological barriers limit commensal colonization in natural settings. To disentangle these effects, we used a controlled perturbation with the antibiotic ciprofloxacin to investigate the dynamics of gut microbiome transmission in 22 households of healthy, cohabiting adults. Colonization was rare in three-quarters of antibiotic-taking subjects, whose resident strains rapidly recovered in the week after antibiotics ended. In contrast, the remaining subjects exhibited lasting responses to antibiotics, with extensive species losses and transient expansions of potential opportunistic pathogens. These subjects experienced elevated rates of commensal colonization, but only after long delays: many new colonizers underwent sudden, correlated expansions months after the antibiotic perturbation. Furthermore, strains that had previously transmitted between cohabiting partners rarely recolonized after antibiotic disruptions, showing that colonization displays substantial historical contingency. This work demonstrates that there remain substantial ecological barriers to colonization even after major microbiome disruptions, suggesting that dispersal interactions and priority effects limit the pace of community change.

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“…LuxR receptors are widespread in proteobacteria and can also be found in microorganisms not known to produce AHL, such as Gram-positive bacteria and archaea . The presence of LuxR solos in non-AHL-producing organisms may allow them to eavesdrop on other bacteria that produce AHL, although studies have demonstrated that LuxR solos can detect other signals (e.g., plant-derived molecules) . The LuxR solo SdiA has been identified in E. coli , Salmonella , and Enterobacter genera, enabling bacteria to respond to AHL detection .…”

Section: Introductionmentioning

confidence: 99%

“…237 The presence of LuxR solos in non-AHL-producing organisms may allow them to eavesdrop on other bacteria that produce AHL, 237 although studies have demonstrated that LuxR solos can detect other signals (e.g., plant-derived molecules). 238 The LuxR solo SdiA has been identified in E. coli, Salmonella, and Enterobacter genera, enabling bacteria to respond to AHL detection. 238 For example, in Salmonella enterica serovar Typhimurium, detection of AHL by SdiA activated specific genes promoting growth in mice, 239 and in S. enterica serovar Enteritidis, the perception of AHL in gut microbiota enhanced motility, biofilm formation, and toxin secretion.…”

Section: ■ Introductionmentioning

confidence: 99%

“…238 The LuxR solo SdiA has been identified in E. coli, Salmonella, and Enterobacter genera, enabling bacteria to respond to AHL detection. 238 For example, in Salmonella enterica serovar Typhimurium, detection of AHL by SdiA activated specific genes promoting growth in mice, 239 and in S. enterica serovar Enteritidis, the perception of AHL in gut microbiota enhanced motility, biofilm formation, and toxin secretion. 240 In Stenotrophomonas maltophilia, the detection of exogenous AHL activated the LuxR solo, SmoR, and enhanced swarming motility.…”

Section: ■ Introductionmentioning

confidence: 99%

See 1 more Smart Citation

AHL-Based Quorum Sensing Regulates the Biosynthesis of a Variety of Bioactive Molecules in Bacteria

Gonzales,

Jacquet,

Gaucher

et al. 2024

J. Nat. Prod.

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Bacteria are social microorganisms that use communication systems known as quorum sensing (QS) to regulate diverse cellular behaviors including the production of various secreted molecules. Bacterial secondary metabolites are widely studied for their bioactivities including antibiotic, antifungal, antiparasitic, and cytotoxic compounds. Besides playing a crucial role in natural bacterial niches and intermicrobial competition by targeting neighboring organisms and conferring survival advantages to the producer, these bioactive molecules may be of prime interest to develop new antimicrobials or anticancer therapies. This review focuses on bioactive compounds produced under acyl homoserine lactone-based QS regulation by Gram-negative bacteria that are pathogenic to humans and animals, including the Burkholderia, Serratia, Pseudomonas, Chromobacterium, and Pseudoalteromonas genera. The synthesis, regulation, chemical nature, biocidal effects, and potential applications of these identified toxic molecules are presented and discussed in light of their role in microbial interactions.

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Deciphering the quorum-sensing lexicon of the gut microbiota

Cited by 11 publications

References 102 publications

A pervasive large conjugative plasmid mediates multispecies biofilm formation in the intestinal microbiota increasing resilience to perturbations

A pervasive large conjugative plasmid mediates multispecies biofilm formation in the intestinal microbiota increasing resilience to perturbations

Prolonged delays in human microbiota transmission after a controlled antibiotic perturbation

AHL-Based Quorum Sensing Regulates the Biosynthesis of a Variety of Bioactive Molecules in Bacteria

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