We study the asymptotic properties of the small data solutions of the Vlasov-Maxwell system in dimension three. No neutral hypothesis nor compact support assumptions are made on the data. In particular, the initial decay in the velocity variable is optimal. We use vector field methods to obtain sharp pointwise decay estimates in null directions on the electromagnetic field and its derivatives. For the Vlasov field and its derivatives, we obtain, as in Fajman et al. (The Stability of the Minkowski space for the Einstein-Vlasov system, 2017. arXiv:1707.06141), optimal pointwise decay estimates by a vector field method where the commutators are modification of those of the free relativistic transport equation. In order to control high velocities and to deal with non integrable source terms, we make fundamental use of the null structure of the system and of several hierarchies in the commuted equations. Contents 894 L. Bigorgne 2.3 Weights preserved by the flow and null components of the velocity vector 904 2.4 Various subsets of the Minkowski spacetime. .