volume 10, issue 5, P1053-1072 2018
DOI: 10.18632/aging.101447
View full text
|
|
Share
Tao Wang, Shao-Lei Geng, Yu-Min Guan, Wei-Hua Xu

Abstract: Diapause in insects is akin to dauer in Caenorhabditis elegans and hibernation in vertebrates. Diapause causes a profound extension of lifespan by low metabolic activity. However, the detailed regulatory mechanisms for low metabolic activity remain unknown. Here, we showed that low pyruvate levels are present in the brains of diapause-destined pupae of the cotton bollworm Helicoverpa armigera, and three enzymes pyruvate kinase (PK), phosphoenolpyruvate carboxykinase (PEPCK), and phosphoglycerate mutase (PGAM) …

expand abstract