De novo synthesis of a MIL-125(Ti) carrier for thermal- and pH-responsive drug release

Lin, Yousheng; Lin, Kuen‐Song; Mdlovu, Ndumiso Vukile; Tsai, Wei-Chin; Jeng, U‐Ser

doi:10.1016/j.bioadv.2022.213070

Cited by 11 publications

(3 citation statements)

References 41 publications

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“…Lin et al [ 5 ] synthesized a pH-responsive MOF, MIL-125(Ti), modified with Pluronic F127 and chitosan monomers and loaded with doxorubicin. The carrier was found to be temperature- and pH-responsive, with the potential for use in cancer treatment.…”

Section: Mofs In Drug Delivery Applicationsmentioning

confidence: 99%

Metal-Organic Frameworks: Versatile Platforms for Biomedical Innovations

Păun,

Motelică,

Ficai

et al. 2023

Materials

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This review article explores the multiple applications and potential of metal-organic frameworks (MOFs) in the biomedical field. With their highly versatile and tunable properties, MOFs present many possibilities, including drug delivery, biomolecule recognition, biosensors, and immunotherapy. Their crystal structure allows precise tuning, with the ligand typology and metal geometry playing critical roles. MOFs’ ability to encapsulate drugs and exhibit pH-triggered release makes them ideal candidates for precision medicine, including cancer treatment. They are also potential gene carriers for genetic disorders and have been used in biosensors and as contrast agents for magnetic resonance imaging. Despite the complexities encountered in modulating properties and interactions with biological systems, further research on MOFs is imperative. The primary focus of this review is to provide a comprehensive examination of MOFs in these applications, highlighting the current achievements and complexities encountered. Such efforts will uncover their untapped potential in creating innovative tools for biomedical applications, emphasizing the need to invest in the continued exploration of this promising field.

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Section: Mofs In Drug Delivery Applicationsmentioning

confidence: 99%

Metal-Organic Frameworks: Versatile Platforms for Biomedical Innovations

Păun,

Motelică,

Ficai

et al. 2023

Materials

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“…A mesoporous carbon hollow sphere (MCHS) is a three-dimensional carbon material with large cavities and porous carbon shells, exhibiting uniform geometry, tunable porosity, a large surface area, and small particle size [29,30]. Consequently, it has been widely applied in catalysis [31], supercapacitors [32], drug release [33], batteries [34], and energy storage [35]. Palladium (Pd) nanoparticles, as noble metal nanomaterials, have garnered considerable research interest owing to their excellent catalytic activity, cost-effectiveness, and abundant availability.…”

Section: Introductionmentioning

confidence: 99%

A Novel Electrochemical Sensor Based on Pd Confined Mesoporous Carbon Hollow Nanospheres for the Sensitive Detection of Ascorbic Acid, Dopamine, and Uric Acid

Zhang,

Li,

Liu

et al. 2024

Molecules

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In this study, we designed a novel electrochemical sensor by modifying a glass carbon electrode (GCE) with Pd confined mesoporous carbon hollow nanospheres (Pd/MCHS) for the simultaneous detection of ascorbic acid (AA), dopamine (DA), and uric acid (UA). The structure and morphological characteristics of the Pd/MCHS nanocomposite and the Pd/MCHS/GCE sensor are comprehensively examined using SEM, TEM, XRD and EDX. The electrochemical properties of the prepared sensor are investigated through CV and DPV, which reveal three resolved oxidation peaks for AA, DA, and UA, thereby verifying the simultaneous detection of the three analytes. Benefiting from its tailorable properties, the Pd/MCHS nanocomposite provides a large surface area, rapid electron transfer ability, good catalytic activity, and high conductivity with good electrochemical behavior for the determination of AA, DA, and UA. Under optimized conditions, the Pd/MCHS/GCE sensor exhibited a linear response in the concentration ranges of 300–9000, 2–50, and 20–500 µM for AA, DA, and UA, respectively. The corresponding limit of detection (LOD) values were determined to be 51.03, 0.14, and 4.96 µM, respectively. Moreover, the Pd/MCHS/GCE sensor demonstrated outstanding selectivity, reproducibility, and stability. The recovery percentages of AA, DA, and UA in real samples, including a vitamin C tablet, DA injection, and human urine, range from 99.8–110.9%, 99.04–100.45%, and 98.80–100.49%, respectively. Overall, the proposed sensor can serve as a useful reference for the construction of a high-performance electrochemical sensing platform.

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“…For MDR, MOF NPs have been utilized to treat bacterial multidrug resistance induced by the abuse of traditional antibiotics [36], as well as cancer multidrug resistance caused by chemotherapy medicines [37,38]. Among the reported MOF NPs, MIL-125 MOF NPs, formed by a titanium ion group, are excellent representatives, but they lack active targeting and only rely on passive targeting by the enhanced permeability and retention effect (EPR effect) [39][40][41][42][43]. This affects the accumulation of drugs in the tumor site to a certain extent.…”

Section: Introductionmentioning

confidence: 99%

Hollow MIL-125 Nanoparticles Loading Doxorubicin Prodrug and 3-Methyladenine for Reversal of Tumor Multidrug Resistance

Guo,

Li,

Mao

et al. 2023

JFB

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Multidrug resistance (MDR) is a key factor in chemotherapy failure and tumor recurrence. The inhibition of drug efflux and autophagy play important roles in MDR therapy. Herein, a multifunctional delivery system (HA-MIL-125@DVMA) was prepared for synergistically reverse tumor MDR. Tumor-targeted hollow MIL-125-Ti nanoparticles were used to load the doxorubicin–vitamin E succinate (DV) prodrug and 3-methyladenine (3-MA) to enhance reverse MDR effects. The pH-sensitive DV can kill tumor cells and inhibit P-gp-mediated drug efflux, and 3-MA can inhibit autophagy. HA-MIL-125@DVMA had uniformly distributed particle size and high drug-load content. The nanoparticles could effectively release the drugs into tumor microenvironment due to the rapid hydrazone bond-breaking under low pH conditions, resulting in a high cumulative release rate. In in vitro cellular experiments, the accumulation of HA-MIL-125@DVMA and HA-MIL-125@DV in MCF-7/ADR cells was significantly higher than that in the control groups. Moreover, the nanoparticles significantly inhibited drug efflux in the cells, ensuring the accumulation of the drugs in cell cytoplasm and causing drug-resistant cells’ death. Importantly, HA-MIL-125@DVMA effectively inhibited tumor growth without changes in body weight in tumor-bearing mice. In summary, the combination of the acid-sensitive prodrug DV and autophagy inhibitor 3-MA in a HA-MIL-125 nanocarrier can enhance the antitumor effect and reverse tumor MDR.

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De novo synthesis of a MIL-125(Ti) carrier for thermal- and pH-responsive drug release

Cited by 11 publications

References 41 publications

Metal-Organic Frameworks: Versatile Platforms for Biomedical Innovations

Metal-Organic Frameworks: Versatile Platforms for Biomedical Innovations

A Novel Electrochemical Sensor Based on Pd Confined Mesoporous Carbon Hollow Nanospheres for the Sensitive Detection of Ascorbic Acid, Dopamine, and Uric Acid

Hollow MIL-125 Nanoparticles Loading Doxorubicin Prodrug and 3-Methyladenine for Reversal of Tumor Multidrug Resistance

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