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Cited by 67 publications
(51 citation statements)
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“…The CV I of urinary albumin we observed was broadly similar to that previously reported (see online Supplemental Table 9), was reduced by adjustment for creatinine concentration, and was highest among those with the lowest levels of albuminuria, as also noted by others (34 ). Urinary NAG showed within-subject biological variability similar to that of KIM-1, including a reduction after adjustment for creatinine and differences in CV I across the patient groups that disappeared after creatinine adjustment.…”
Section: Timp-2 Is a Relatively New Marker Of Aki (10 )supporting
confidence: 88%
“…The CV I of urinary albumin we observed was broadly similar to that previously reported (see online Supplemental Table 9), was reduced by adjustment for creatinine concentration, and was highest among those with the lowest levels of albuminuria, as also noted by others (34 ). Urinary NAG showed within-subject biological variability similar to that of KIM-1, including a reduction after adjustment for creatinine and differences in CV I across the patient groups that disappeared after creatinine adjustment.…”
Section: Timp-2 Is a Relatively New Marker Of Aki (10 )supporting
confidence: 88%
“…It cannot detect changes in proteinuria over the course of the day or take into account orthostatic changes that can potentially cause relevant changes in proteinuria. Moreover, likely day-to-day biological variation of the UPC-ratio has to be considered and only relatively large changes indicate a reliable change in disease status [10] . Proteinuria is known to have a circadian rhythm so when samples for the calculation of UPC ratio are collected at a fixed time of the day UPC ratio can be an acceptable alternative for 24-h urine collections, especially in an outpatient setting [11] .…”
Section: Proteinuria In Pregnancymentioning
confidence: 99%
“…The risk relationship between albuminuria and adverse events clearly extends into this range, but deciding on cut-off points is especially difficult, since there is no threshold effect and information on cost-effectiveness of interventions in this group is very sparse. Still, our study indicates that other gender-specific considerations should be made in such low-grade albuminuria: a substantial intra-individual day-to-day variability in UAE has previously been described [9,10,33,34]. We demonstrated significantly lower reliability and higher coefficient of variation for repeated ACR measurements in women.…”
Section: Discussionmentioning
confidence: 44%
“…Furthermore, day-to-day variability in urinary albumin excretion (UAE) can be substantial (25-50%), reflecting both biological variability and changes in disease status [9,10]. Urinary creatinine excretion is also lower in women [11]; therefore, some previous guidelines suggest different albumin-creatinine ratio (ACR) cut-off values for diabetic men and women [12,13,14].…”
Section: Introductionmentioning
confidence: 99%