Day three versus day two embryo transfer following in vitro fertilization or intracytoplasmic sperm injection

Abstract

Although an increase in clinical pregnancy rate with day three embryo transfer was demonstrated, at present there is not sufficient good quality evidence to suggest an improvement in live birth when embryo transfer is delayed from day two to day three.

A Comparative Analysis Between Day 2 and Day 3 Embryo Transfer in IVF/ICSI: A Retrospective Cross-Sectional Study

“…The authors mentioned that if culture conditions are optimized, no differences would be seen in pregnancy rate after ET on day 1or day 2. In other studies, embryos transferred on day 2 were comparable to day 3 (5,6,(17)(18)(19)(20). Although in these studies, in patients with good prognosis, fewer embryos were transferred, in our survey, between the two groups, the number of embryos transferred remained unchanged.…”

A Comparative Analysis Between Day 2 and Day 3 Embryo Transfer in IVF/ICSI: A Retrospective Cross-Sectional Study

“…The authors mentioned that if culture conditions are optimized, no differences would be seen in pregnancy rate after ET on day 1or day 2. In other studies, embryos transferred on day 2 were comparable to day 3 (5,6,(17)(18)(19)(20). Although in these studies, in patients with good prognosis, fewer embryos were transferred, in our survey, between the two groups, the number of embryos transferred remained unchanged.…”

Vitrification of day 3 cleavage-stage embryos yields better clinical outcome in comparison with vitrification of day 2 cleavage-stage embryos

“…It was observed that delaying fresh ET from day 2 to day 3 could yield increased pregnancy rates through better selection of good-quality embryos (Oatway et al ., 2004 ), although a previous study showed that the implantation and pregnancy rates were comparable for day 2 and day 3 ET (Laverge et al ., 2001 ). Prolonging the duration of culture in vitro before freezing could increase the possibility of obtaining more high quality embryos for cryopreservation, with better developmental potential.…”

Efficacy of embryo transfer on day 2 versus day 3 according to maternal age in patients with normal ovarian response

“…In 1984, Edwards et al [ 16 ] reported that the incidence of miscarriage after day 3 ET was higher than that for day 2 ET. A previous meta-analysis showed that the clinical pregnancy rate was higher with day 3 ET, but the higher miscarriage rates with day 3 ET negated the increased pregnancy rate and resulted in no difference in live births [ 3 ].…”

A Comparative Analysis Between Day 2 and Day 3 Embryo Transfer in IVF/ICSI: A Retrospective Cross-Sectional Study

“…The authors mentioned that if culture conditions are optimized, no differences would be seen in pregnancy rate after ET on day 1or day 2. In other studies, embryos transferred on day 2 were comparable to day 3 (5,6,(17)(18)(19)(20). Although in these studies, in patients with good prognosis, fewer embryos were transferred, in our survey, between the two groups, the number of embryos transferred remained unchanged.…”

Vitrification of day 3 cleavage-stage embryos yields better clinical outcome in comparison with vitrification of day 2 cleavage-stage embryos

“…It was observed that delaying fresh ET from day 2 to day 3 could yield increased pregnancy rates through better selection of good-quality embryos (Oatway et al ., 2004 ), although a previous study showed that the implantation and pregnancy rates were comparable for day 2 and day 3 ET (Laverge et al ., 2001 ). Prolonging the duration of culture in vitro before freezing could increase the possibility of obtaining more high quality embryos for cryopreservation, with better developmental potential.…”

Efficacy of embryo transfer on day 2 versus day 3 according to maternal age in patients with normal ovarian response

“…In 1984, Edwards et al [ 16 ] reported that the incidence of miscarriage after day 3 ET was higher than that for day 2 ET. A previous meta-analysis showed that the clinical pregnancy rate was higher with day 3 ET, but the higher miscarriage rates with day 3 ET negated the increased pregnancy rate and resulted in no difference in live births [ 3 ].…”

A Comparative Analysis Between Day 2 and Day 3 Embryo Transfer in IVF/ICSI: A Retrospective Cross-Sectional Study

“…The authors mentioned that if culture conditions are optimized, no differences would be seen in pregnancy rate after ET on day 1or day 2. In other studies, embryos transferred on day 2 were comparable to day 3 (5,6,(17)(18)(19)(20). Although in these studies, in patients with good prognosis, fewer embryos were transferred, in our survey, between the two groups, the number of embryos transferred remained unchanged.…”

Vitrification of day 3 cleavage-stage embryos yields better clinical outcome in comparison with vitrification of day 2 cleavage-stage embryos

“…It was observed that delaying fresh ET from day 2 to day 3 could yield increased pregnancy rates through better selection of good-quality embryos (Oatway et al ., 2004 ), although a previous study showed that the implantation and pregnancy rates were comparable for day 2 and day 3 ET (Laverge et al ., 2001 ). Prolonging the duration of culture in vitro before freezing could increase the possibility of obtaining more high quality embryos for cryopreservation, with better developmental potential.…”

Efficacy of embryo transfer on day 2 versus day 3 according to maternal age in patients with normal ovarian response

“…In 1984, Edwards et al [ 16 ] reported that the incidence of miscarriage after day 3 ET was higher than that for day 2 ET. A previous meta-analysis showed that the clinical pregnancy rate was higher with day 3 ET, but the higher miscarriage rates with day 3 ET negated the increased pregnancy rate and resulted in no difference in live births [ 3 ].…”