Day‐Long Reduction of Oral Malodor by a Two‐Phase Oil:Water Mouthrinse as Compared to Chlorhexidine and Placebo Rinses

Abstract

Few scientific investigations have addressed the ability of mouthrinses to reduce oral malodor for periods longer than 3 hours. In the present report, we have employed simple, recently described techniques to assess the day‐long reduction in oral malodor of a novel 2‐phase oil:water mouthrinse (TPM), as compared to a corresponding placebo rinse, and to a commercial 0.2% chlorhexidine mouthrinse. Sixty dental students were divided randomly into 3 groups, and instructed to use one of the rinses prior to bedtime and the following morning. Measurements carried out in the late afternoon, about 8 to 10 hours following rinsing, were compared with baseline measurements carried out in the late afternoon of the previous day. Volatile sulphide levels were measured using a portable industrial sulphide monitor. Microbial levels were estimated using a simple rinsing technique employing sterilized milk. These quantitative techniques were corroborated by organoleptic (hedonic) ratings of a single odor judge. Both TPM and Chlorhexidine brought about significant decreases in volatile sulphides (P < 0.05) as compared to the placebo group. These results were corroborated by the organoleptic data. Similarly, both chlorhexidine and TPM were highly effective in reducing microbial levels as measured by the rinsing technique, in comparison to the placebo group. Chlorhexidine appeared to be more effective than TPM in all measurement categories, although only in the case of microbial activity was there a significant (P < 0.05) difference between the two groups. The data showing daylong reduction of malodorous sulphides and microbial levels by TPM extend previous in vitro studies demonstrating its potent microbial desorption properties, and provide the first evidence for its potential clinical efficacy. J Periodontol 1992;63:39–43.

Comparative Efficacy of Oil Pulling and Chlorhexidine on Oral Malodor : A Randomized Controlled Trial

“…It provides a significant reduction in volatile sulphur compounds (VSC) levels and organoleptic scores (ORG) because of its strong antibacterial effects and superior substantivity in the oral cavity [2,[26][27][28]. Hence, it was used as the positive control in this present clinical trial.…”

Inhibitory Effects of Zinc Chloride and Citric Acid on Release of Volatile Sulfur Compounds

“…In the United States, combinations of chlorhexidine with other substances, which kill VSC-producing bacteria in the oral cavity, are commercially available [8][9][10] . However, an immediate effect is not produced by such formulations.…”

“…However, an immediate effect is not produced by such formulations. Moreover, mouth rinses containing essential oils and ethanol are commercially available, but toxicity is a problem with formulations containing more than 25% ethanol 10) .…”

The Inhibitory Effect of Bismuth Oxychloride in Halithosis Caused by Volatile Sulfur Compounds

“…In the United States, the combining chlorhexidine with other substances in disinfecting VSC-producing bacteria in the oral cavity are commercially available [11][12][13] . However, immediate effect would not be expected in such formulations.…”