Davilla elliptica and Davilla nitida: Gastroprotective, anti-inflammatory immunomodulatory and anti-Helicobacter pylori action

Abstract

The phytochemical investigation showed that both extracts possess phenolic acid derivatives, acylglycoflavonoids and condensed tannins with evident quantitative variations that probably influenced the pharmacological differences between extracts.

Effect of Mouriri pusa tannins and flavonoids on prevention and treatment against experimental gastric ulcer

“…It is an important enzyme for the gastric mucosa because it, in cicatrisation process, induces angiogenesis, cell proliferation and cytoprotection, related to the production of prostaglandins that stimulates mucus and bicarbonate production (Brzozowski et al, 2000). Kushima et al (2009) studying Flavonoid fraction from Davilla elliptica observed that the number of COX-2 marked cells lowers dose-dependently, which confirms flavonoids antiinflammatory effect by inhibition of COX-2 (Robak and Gryglewski, 1996). In the study of the Tannins fraction from Davilla elliptica by Kushima et al (2009), COX-2 expression tended to rise also dose dependently, although it was not related to the mechanism of action of this plant.…”

A etnobotânica aplicada à úlcera gástrica e avaliação farmacológica de Solanum stipulaceum

“…Diversos estudos sobre atividade biológica de plantas medicinais contendo taninos e flavonoides evidenciaram dentre outras ações a cura de feridas, atividades antiinflamatória, antiulcerogênica gástrica e antioxidante (Kushima et al, 2009;Moleiro et al, 2009). Taninos podem interagir com as proteínas do muco, melhorando seu efeito citoprotetor pela formação de um revestimento proteico na mucosa gastrintestinal (Okuda, 2005;Moleiro et al, 2009).…”

Spices as Alternative Agents for Gastric Ulcer Prevention and Treatment

“…Besides its H. pylori bactericidal effect, Davilla elliptica also enhances NO, H 2 O 2 , TNFproduction and GSH bioavailability. These activities are related to its phytochemical constituents acylglycoflavonoids, phenolic acid derivatives and tannins (74). Also Brazilian medicinal plant methanolic extracts have an anti-H. pylori effect and protect the gastric mucosa by increasing PGE2, antisecretory and gastroprotective properties (75) The gastroprotection of Vochysia tucanorum Mart.…”

“…In disparity, many spices and plant extracts, in commonly used dose, up to 500mg/kg body weight have not exhibited adverse effect. These include cardamom (62,68), black pepper (66), clove (67), caraway (69), saffron (70),coriander(71), peppermint (72), anise (73), davilla elliptica and nitida (74) ,Brazilian medical plants (75) and Alchornea triplinervia (76) and Hyptis spicigera Lam (86). Even in pregnancy, ginger, peppermint, and Cannabis have been used to treat nausea were effective and lack clinical evidence of harm (165).…”