Daunorubicin reductase activity in human normal lymphocytes, myeloblasts and leukemic cell lines

Role of DNA Methylation on the Expression of the Anthracycline Metabolizing Enzyme AKR7A2 in Human Heart

“…For example, one can envision a diagnostic scenario in which the maximal synthesis rates of doxorubicinol in the heart tissue of cancer patients undergoing chemotherapy with anthracyclines are inferred from a readily accessible “proxy” such as peripheral blood lymphocytes trough inter-tissue extrapolation approaches (10, 11). Peripheral blood lymphocytes have substantial CBR/AKR activity toward anthracycline substrates (12, 13). This is because lymphocytes express CBRs and AKRs, including AKR7A2 (14, 15).…”

Role of DNA Methylation on the Expression of the Anthracycline Metabolizing Enzyme AKR7A2 in Human Heart

“…For example, one can envision a diagnostic scenario in which the maximal synthesis rates of doxorubicinol in the heart tissue of cancer patients undergoing chemotherapy with anthracyclines are inferred from a readily accessible “proxy” such as peripheral blood lymphocytes trough inter-tissue extrapolation approaches (10, 11). Peripheral blood lymphocytes have substantial CBR/AKR activity toward anthracycline substrates (12, 13). This is because lymphocytes express CBRs and AKRs, including AKR7A2 (14, 15).…”

Role of DNA Methylation on the Expression of the Anthracycline Metabolizing Enzyme AKR7A2 in Human Heart

“…For example, one can envision a diagnostic scenario in which the maximal synthesis rates of doxorubicinol in the heart tissue of cancer patients undergoing chemotherapy with anthracyclines are inferred from a readily accessible “proxy” such as peripheral blood lymphocytes trough inter-tissue extrapolation approaches (10, 11). Peripheral blood lymphocytes have substantial CBR/AKR activity toward anthracycline substrates (12, 13). This is because lymphocytes express CBRs and AKRs, including AKR7A2 (14, 15).…”

Role of DNA Methylation on the Expression of the Anthracycline Metabolizing Enzyme AKR7A2 in Human Heart

“…For example, one can envision a diagnostic scenario in which the maximal synthesis rates of doxorubicinol in the heart tissue of cancer patients undergoing chemotherapy with anthracyclines are inferred from a readily accessible “proxy” such as peripheral blood lymphocytes trough inter-tissue extrapolation approaches (10, 11). Peripheral blood lymphocytes have substantial CBR/AKR activity toward anthracycline substrates (12, 13). This is because lymphocytes express CBRs and AKRs, including AKR7A2 (14, 15).…”