Database of mutations in the p53 and APC tumor suppressor genes designed to facilitate molecular epidemiological analyses

Abstract

Germline and somatic mutations in the p53 and APC genes contribute to neoplasia. The patterns of these and other acquired mutations in cancers reflect environmental mutagens and endogenous factors that contribute to carcinogenesis. Herein, we describe a database of almost 2,300 mutations in the p53 and APC genes published until September 1, 1993. In addition to cataloging the mutations, multiple fields of information have been added to facilitate future molecular epidemiological analyses of human cancer. The accuracy of the database has been checked by the present authors and, by soliciting feedback from the original corresponding authors. The strengths and limitations of the primary literature are discussed. © 1996 Wiley‐Liss, Inc.

Type of TP53 mutation and ERBB2 amplification affects survival in node-negative breast cancer

“…Thus, 30% of TP53 mutations would have been missed in studies focusing only to exons 5-8 of the TP53 gene. Other studies have also shown that a considerable fraction of protein truncating mutations occurs outside the evolutionary conserved region of TP53 [3,28].…”

Supplementary Figure Legends from CD44v8-10 Is a Cancer-Specific Marker for Gastric Cancer Stem Cells

“…Mutations of p53 in the indicated xenograft lines were determined by Sanger sequencing of cDNA generated by reverse transcription polymerase chain reaction. R175C is a known mutation in colon and uterine cancer [1] that has been reported to retain wild-type functions [2]. R273C is a known mutation in multiple cancers [1].…”

“…R175C is a known mutation in colon and uterine cancer [1] that has been reported to retain wild-type functions [2]. R273C is a known mutation in multiple cancers [1]. N239 insertion is a novel mutation in the DNA binding domain of p53.…”