Data Envelopment Analysis and Decision Maker Models: An Innovative Approach for Optimization of Reaction Variables of Graft Copolymerization of Poly(butyl acrylate) to Tamarind Seed Xyloglucan

Yadav, Ravindra Nath; Malhotra, AnnuVij; Mishra, Anuradha

doi:10.1002/mats.202000051

Cited by 1 publication

(1 citation statement)

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“…Moreover, atom transfer radical polymerization (ATRP) has been demonstrated experimentally to achieve the grafting of poly(methyl methacrylate) (PMMA) for use in removing toxic dyes [ 18 ]. Our group has previously grafted ethyl acrylate onto tamarind xyloglucans using free radicals to generate biodegradable films [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

Preparation of xyloglucan-grafted poly(N-hydroxyethyl acrylamide) copolymer by free-radical polymerization for in vitro evaluation of human dermal fibroblasts

González-Torres,

Martínez-Mata,

Ruvalcaba-Paredes

et al. 2024

J Mater Sci: Mater Med

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Xyloglucan is a rigid polysaccharide that belongs to the carbohydrate family. This hemicellulose compound has been widely used in biomedical research because of its pseudoplastic, mucoadhesive, mucomimetic, and biocompatibility properties. Xyloglucan is a polyose with no amino groups in its structure, which also limits its range of applications. It is still unknown whether grafting hydrophilic monomers onto xyloglucan can produce derivatives that overcome these shortcomings. This work aimed to prepare the first copolymers in which N-hydroxyethyl acrylamide is grafted onto tamarind xyloglucan by free-radical polymerization. The biocompatibility of these structures in vitro was evaluated using human dermal fibroblasts. Gamma radiation-induced graft polymerization was employed as an initiator by varying the radiation dose from 5–25 kGy. The structure of the graft copolymer, Xy-g-poly(N-hydroxyethyl acrylamide), was verified by thermal analysis, Fourier transform infrared spectroscopy, and nuclear magnetic resonance spectroscopy. The findings indicate that the degree of grafting and the cytotoxicity/viability of the xyloglucan-based copolymer were independent of dose. Notably, the grafted galactoxyloglucan exhibited efficient support for human dermal fibroblasts, showing heightened proliferative capacity and superior migration capabilities compared to the unmodified polymer. This copolymer might have the potential to be used in skin tissue engineering.

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Section: Introductionmentioning

confidence: 99%