Objective-To systematically review evidence on the prevention and treatment of pressure ulcers in those with a spinal cord injury.Data Sources-For this evidence-based review, the following data sources were used: MEDLINE ® /PubMed, CINAHL ® , EMBASE ® and PsycINFO ® Study Selection-To be selected for inclusion in the current review, there had to have been an intervention, studies had to have 3 or more subjects, and 50% or more of the participating group had to have a spinal cord injury.Data Extraction-Data extracted included study design, subject demographics, inclusion and exclusion criteria, study type, sample size, outcome measures used, and study results.Data Synthesis-Articles selected for this review were organized into one of two categories: prevention or treatment. Within each broad category, several smaller ones were created and articles were grouped together according to the prevention (direct or indirect) or treatment intervention discussed.Conclusions-Of the 26 articles selected for inclusion in the systematic review, 7 were randomized control trials that dealt with treatment for pressure ulcers, and there was one RCT on prevention. Despite the cost effectiveness of prevention, little research exists on preventative interventions, and what does exist mostly is Level 4 evidence. More research is needed for both prevention and treatment, but especially the former.