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Cited by 283 publications
(150 citation statements)
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“…Conjugation of cholate to the sulfonic acid alkyl linker by an ester was prepared following established protocols for Fischer esterification (10,16,33). Briefly, to a solution of cholate (1 equivalent) and hydroxy ethane sulfonic acid (4 equivalents), concentrated sulfuric acid was added dropwise and refluxed for 1 h. The reaction mixture was poured into cold diethyl ether, and a precipitate formed immediately.…”
Section: Methodsmentioning
confidence: 99%
“…Conjugation of cholate to the sulfonic acid alkyl linker by an ester was prepared following established protocols for Fischer esterification (10,16,33). Briefly, to a solution of cholate (1 equivalent) and hydroxy ethane sulfonic acid (4 equivalents), concentrated sulfuric acid was added dropwise and refluxed for 1 h. The reaction mixture was poured into cold diethyl ether, and a precipitate formed immediately.…”
Section: Methodsmentioning
confidence: 99%
“…In this context, some protocols for the synthesis of esters are well-known, including Fisher esterifications [2] and methylation reactions [3] of carboxylic acids. Due to the wide synthetic and biological applications of esters, a number of reagents such as ortho esters [4], N , N -dimethylformamide dialkyl acetals [5], triazene derivatives [6] and O -dialkyl isoureas [7] have been reported for the esterification of various aromatic/aliphatic carboxylic acids.…”
Section: Introductionmentioning
confidence: 99%
“…1 and their nomenclature is adapted from [6], which also describes their syntheses. Using the standard SPE method for basic drugs [21], an unexpected methylation (Fischer esterification) of the carboxyl group of the major zwitterionic metabolite H117/04 by methanol was observed [23]. The present paper describes the results of these studies.…”
Section: Introductionmentioning
confidence: 92%