Dark-rim-free ungated first-pass perfusion CMR with 3-Slice end-systolic imaging: initial experience

Sharif, Behzad; Arsanjani, Reza; Shaleṿ, Aryeh; Dharmakumar, Rohan; Merz, C. Noel Bairey; Berman, Daniel S.; Li, Debiao

doi:10.1186/1532-429x-16-s1-p177

Cited by 2 publications

(3 citation statements)

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“…However, the reliance on ECG gating for systolic acquisition in such approaches imposes practical difficulties and could compromise the image quality in stress imaging studies (due to variable/short R‐R intervals). Following our initial reports , the in vivo results presented in this work are the first demonstration of a magnetization‐driven FPP method capable of imaging multiple myocardial slices at the same systolic phase without needing to acquire an ECG signal or other forms of cardiac synchronization. Our results show that the proposed continuously sampled method can yield high‐resolution images for three short‐axis slices (Figs.…”

Section: Discussionmentioning

confidence: 81%

“…Our data acquisition approach in this work belongs to the class of magnetization‐driven FPP pulse sequences , which unlike conventional FPP approaches do not use a magnetization‐preparation pulse (saturation/inversion recovery) and instead rely on the T1 contrast generated by the approximate steady‐state following/during a radiofrequency (RF) pulse train. Based on our previous approach , a multislice RF‐spoiled non–ECG‐gated GRE pulse sequence was developed , capable of acquiring multiple short‐axis slices in a continuous slice‐interleaved manner along a golden‐ratio radial k‐space trajectory (111.246° angular spacing between consecutive radial readouts). The sequence is demonstrated in Figure , which also highlights the main differences of the proposed acquisition scheme compared with the SR‐prepared “ conventional FPP ” pulse sequence.…”

Section: Methodsmentioning

confidence: 99%

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All-systolic non-ECG-gated myocardial perfusion MRI: Feasibility of multi-slice continuous first-pass imaging

et al. 2015

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Purpose To develop and test the feasibility of a new method for non-ECG-gated first-pass perfusion (FPP) cardiac MR capable of imaging multiple short-axis slices at the same systolic cardiac phase. Methods A magnetization-driven pulse sequence was developed for non-ECG-gated FPP imaging without saturation-recovery preparation using continuous slice-interleaved radial sampling. The image reconstruction method, dubbed TRACE, employed self-gating based on reconstruction of a real-time image-based navigator combined with reference-constrained compressed sensing. Data from ischemic animal studies (n=5) was used in a simulation framework to evaluate temporal fidelity. Healthy subjects (n=5) were studied using both the proposed and conventional method to compare the myocardial contrast-to-noise ratio (CNR). Patients (n=2) underwent adenosine stress studies using the proposed method. Results Temporal fidelity of the developed method was shown to be sufficient at high heart-rates. The healthy volunteers studies demonstrated normal perfusion and no artifacts. Compared to the conventional scheme, myocardial CNR for the proposed method was slightly higher (8.6±0.6 vs. 8.0±0.7). Patient studies showed stress-induced perfusion defects consistent with invasive angiography. Conclusions The presented methods and results demonstrate feasibility of the proposed approach for high-resolution non-ECG-gated FPP imaging and indicate its potential for achieving desirable image quality (high CNR, no dark-rim artifacts) with a 3-slice spatial coverage, all imaged at the same systolic phase.

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Section: Discussionmentioning

confidence: 81%

Section: Methodsmentioning

confidence: 99%

All-systolic non-ECG-gated myocardial perfusion MRI: Feasibility of multi-slice continuous first-pass imaging

et al. 2015

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“…This method is also needs to be validated for stress imaging. However, similar methods have been shown to be applicable to stress imaging and at high heart‐rates .…”

Section: Discussionmentioning

confidence: 99%

Quantification of myocardial blood flow using non–ECG‐triggered MR imaging

Chen

Sharif

Dharmakumar

et al. 2014

Magnetic Resonance in Med

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Purpose MR myocardial perfusion imaging is dependent on reliable electrocardiogram (ECG) triggering for accurate measurement of myocardial blood flow (MBF). A non-ECG-triggered method for quantitative first-pass imaging may improve clinical feasibility in patients with poor ECG signal. The purpose of this study is to evaluate the feasibility of a non-ECG-triggered method for myocardial perfusion imaging in a single slice. Methods The proposed non-ECG-triggered technique utilizes a saturation-recovery magnetization preparation and golden-angle radial acquisition for integrated arterial input function (AIF) measurement. Image based self-gating with a temporal resolution of 42.6 ms is used to generate a first-pass image series with consistent cardiac phase. The AIF is measured using beat-by-beat T1 estimation of the ventricular blood pool. The proposed technique was performed on 14 healthy volunteers and compared against a conventional ECG-triggered dual-bolus acquisition. Results The proposed method produced MBF with no significant difference compared to ECG-triggered technique (mean of 0.63 ± 0.22 ml/min/g to 0.73 ± 0.21 ml/min/g). Conclusion We have developed a non-ECG-triggered perfusion imaging method with T1 based measurement of the AIF in a single slice. In this preliminary study, our results demonstrate that MBF measured using the proposed method is comparable to the conventional ECG-triggered method.

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Dark-rim-free ungated first-pass perfusion CMR with 3-Slice end-systolic imaging: initial experience

Cited by 2 publications

References 1 publication

All-systolic non-ECG-gated myocardial perfusion MRI: Feasibility of multi-slice continuous first-pass imaging

All-systolic non-ECG-gated myocardial perfusion MRI: Feasibility of multi-slice continuous first-pass imaging

Quantification of myocardial blood flow using non–ECG‐triggered MR imaging

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