Dark matter: Developing a new nanoantioxidant-based therapeutic system for the treatment of age-related macular degeneration

Kwon, Yong-Su; Voinov, Maxim A.; Zheng, Min; Smirnov, Alex I.; Han, Zongchao

doi:10.1016/j.nantod.2023.101879

Cited by 10 publications

(7 citation statements)

References 44 publications

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“…In this study, we present a rationally engineered and advanced strategy for replenishing melanin in the RPE. PDA, a synthetic polymer inspired by natural melanin, has emerged as an attractive therapeutic nanomaterial due to its photoprotection, biocompatibility, and antioxidant activities[18,20]. Moreover, the in vivo trafficking study via single-dose IVT injection demonstrated PDA prefer to accumulate in the RPE layer for up to 3 months, as found in an earlier study[19].…”

Section: Discussionmentioning

confidence: 81%

“…PDA has emerged as an antioxidant with a similar ROS-scavenging ability to natural RPE melanin[19,20,22]. Given that blue light induces the overproduction of ROS in retinal cells[23,24], the ROS-scavenging ability of PDA becomes especially important in suppressing ROS-induced cell damage.…”

Section: Resultsmentioning

confidence: 99%

“…The 2,2-diphenyl-1-picrylhydrazyl (DPPH•, Sigma–Aldrich) assay was performed following a previously described method with slight modifications[20]. Diluted DPPH• working solution (0.1 mM, in 95% ethanol) was added to various concentrations of PDA solution, resulting in final PDA concentrations of 0, 5, 10, 30, 50, 100 and 150 μg mL −1 , respectively.…”

Section: Methodsmentioning

confidence: 99%

“…These factors could lead to an increased risk of excess production of ROS in retinal cells, contributing to the pathogenesis of AMD. Polydopamine nanoparticles, which share similar physical and chemical properties with natural eumelanin in RPE cells[18–20], possess excellent biocompatibility and may provide a new opportunity for supporting the performance improvement of natural RPE melanin.…”

Section: Introductionmentioning

confidence: 99%

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Polydopamine Nanoparticles as Mimicking RPE Melanin for the Protection of Retinal Cells Against Blue Light-Induced Phototoxicity

Kwon,

Zheng,

Smirnov

et al. 2024

Preprint

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Exposure of the eyes to blue light can induce the overproduction of reactive oxygen species (ROS) in the retina and retinal pigment epithelium (RPE) cells, potentially leading to pathological damage of age-related macular degeneration (AMD). While the melanin in RPE cells absorbs blue light and prevents ROS accumulation, the loss and dysfunction of RPE melanin due to age-related changes may contribute to photooxidation toxicity. Herein, we present a novel approach utilizing a polydopamine-replenishing strategy via a single-dose intravitreal (IVT) injection to protect retinal cells against blue light-induced phototoxicity. To investigate the effects of overexposure to blue light on retinal cells, we created a blue light exposure Nrf2-deficient mouse model, which are susceptible to light-induced retinal lesions. After blue light irradiation, we observed retina degeneration and an overproduction of ROS. The Polydopamine-replenishing strategy demonstrated effectiveness in maintaining retinal structural integrity and preventing retina degeneration by reducing ROS production in retinal cells against the phototoxicity of blue light exposure. Our findings highlight the potential of polydopamine as a simple and effective replenishment for providing photoprotection against high-energy blue light exposure.

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Section: Discussionmentioning

confidence: 81%

Section: Resultsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Polydopamine Nanoparticles as Mimicking RPE Melanin for the Protection of Retinal Cells Against Blue Light-Induced Phototoxicity

Kwon,

Zheng,

Smirnov

et al. 2024

Preprint

Self Cite

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“…[51] Furthermore, the integration of CeNPs into melanin-like nanoparticles endowed multiantioxidative activity against reactive oxygen and nitrogen species, while reducing the level of proinflammatory cytokines, ultimately alleviating AMD-like pathology in a laser-induced CNV mouse model. [52] Solid lipid nanoparticles coloaded with microRNA-150, which regulates pathological angiogenesis, and quercetin as an antioxidant and anti-inflammatory drug, demonstrated a promising suppressive effect on the generation and progression of CNV in vivo. [53] Cell-penetrating peptides, resveratrol, and metformin were successfully incorporated into polycaprolactone nanoparticles to enhance retinal penetration, provide antioxidative and anti-inflammatory activities, and inhibit CNV formation, ultimately demonstrating substantial mitigation of disease progression in a light-induced retinal degeneration rat model.…”

Section: Resultsmentioning

confidence: 99%

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age‐Related Macular Degeneration

Choi,

Kim,

Kim

2023

Advanced NanoBiomed Research

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Age‐related macular degeneration (AMD), the leading cause of vision loss among older individuals, is characterized by damage to photoreceptors and retinal pigment epithelial cells (RPEs). Oxidative stress and chronic inflammation in the retina play notable roles in AMD pathogenesis, rendering them attractive therapeutic targets. Cerium oxide nanoparticles (CeNPs) have shown promise in scavenging reactive oxygen species (ROS) by mimicking antioxidant enzymes, whereas mesoporous materials have emerged as versatile drug carriers. Herein, mesoporous CeNPs (mCeNPs) that integrate the advantages of CeNPs and mesoporous materials are presented. The mCeNPs can be synthesized using 1,1′‐carbonyldiimidazole and imidazole in acetone without heating and pressurization. The resulting mCeNPs exhibit mesoporous structures comprising assembled small CeNPs, exerting excellent ROS‐scavenging capabilities, biocompatibility, and cytoprotective and anti‐inflammatory effects against H2O2‐induced damage in RPEs. Using a sodium iodate‐induced AMD mouse model, it is demonstrated that intravitreal mCeNP administration can exhibit disease‐preventive effects. These findings indicate the therapeutic potential of mCeNPs against AMD.

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Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management

Zhou,

Xu,

Shen

et al. 2024

Adv Healthcare Materials

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As an indispensable part of the human sensory system, visual acuity may be impaired and even develop into irreversible blindness due to various ocular pathologies. Among ocular diseases, fundus neovascularization diseases (FNDs) are prominent etiologies of visual impairment worldwide. Intravitreal injection of anti‐vascular endothelial growth factor drugs remains the primary therapy but is hurdled by common complications and incomplete potency. To renovate the current therapeutic modalities, nanomedicine emerged as the times required, which has been endowed with advanced capabilities, able to fulfill the effective ocular fundus drug delivery and achieve precise drug release control, thus further improving the therapeutic effect. This review provides a comprehensive summary of advances in nanomedicine for FND management from state‐of‐the‐art studies. Firstly, we thoroughly introduce the current therapeutic modalities for FNDs, focusing on the key challenges of ocular fundus drug delivery. Secondly, we comprehensively reviewed nanocarriers for ocular posterior drug delivery based on the nanostructures: polymer‐based nanocarriers, lipid‐based nanocarriers, and inorganic nanoparticles. Thirdly, we elaborate on the characteristics of the fundus microenvironment, their pathological changes during FNDs, and corresponding strategies for constructing smart nanocarriers. Furthermore, the challenges and prospects of nanomedicine for FND management are thoroughly discussed.This article is protected by copyright. All rights reserved

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Dark matter: Developing a new nanoantioxidant-based therapeutic system for the treatment of age-related macular degeneration

Cited by 10 publications

References 44 publications

Polydopamine Nanoparticles as Mimicking RPE Melanin for the Protection of Retinal Cells Against Blue Light-Induced Phototoxicity

Polydopamine Nanoparticles as Mimicking RPE Melanin for the Protection of Retinal Cells Against Blue Light-Induced Phototoxicity

Mesoporous Cerium Oxide Nanoparticles with High Scavenging Properties of Reactive Oxygen Species for Treating Age‐Related Macular Degeneration

Recent Advances in Nanomedicine for Ocular Fundus Neovascularization Disease Management

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