Dapsone for the treatment of acne vulgaris: do the risks outweigh the benefits?

Temiz, Selami Aykut; Daye, Munise

doi:10.1080/15569527.2021.2024565

Cited by 6 publications

(3 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The bulk of treatments used to treat AV at the moment are antibiotics and synthetic retinoids, which are synthetic chemicals 9 . However, these medications have the potential to increase photosensitivity, immunological hypersensitivity, and skin irritation and dryness 10 .…”

Section: Discussionmentioning

confidence: 99%

Meconopsis quintuplinervia Regel Improves Cutibacterium acnes-Induced Inflammatory Responses in a Mouse Ear Edema Model and Suppresses Pro-Inflammatory Chemokine Production via the MAPK and NF-κB Pathways in RAW264.7 Cells

Gao,

Xie,

Zhang

et al. 2023

Ann Dermatol

View full text Add to dashboard Cite

Background Acne vulgaris (AV) is a common adolescent skin condition which is mainly caused by Cutibacterium acnes overcolonization and subsequent inflammation. Objective Our previous studies demonstrated that ethanol extracts of Meconopsis quintuplinervia Regel (EMQ) possess significant antimicrobial properties. However, their protective effects and potential mechanisms against AV remain unclear. Methods In the present study, the EMQ treatment potential for AV was evaluated in a C. acnes -induced mouse ear edema model, and the EMQ anti-inflammatory mechanism was evaluated in lipopolysaccharide (LPS)-induced RAW264.7 macrophage cells. Results The results showed that EMQ alleviated edema formation and inflammatory cell infiltration in an acne mouse model by suppressing inflammatory cytokines interleukin (IL)-6, IL-1β, and tumor necrosis factor α expression. Moreover, EMQ inhibited the phosphorylation of MAP kinases (MAPKs) such as p38, JNK, and ERK, the phosphorylation and degradation of IκB-α and the nuclear translocation of nuclear factor kappa B (NF-κB) p65 in LPS-induced RAW264.7 cells. Conclusion These findings suggest the potent anti-inflammatory activity of EMQ is possibly through the regulation of the MAPKs and NF-κB signaling pathways. Inhibition of C. acnes activity combined with a powerful anti-inflammatory effect of EMQ indicated its potential as a novel therapeutic option for AV.

show abstract

Section: Discussionmentioning

confidence: 99%

Meconopsis quintuplinervia Regel Improves Cutibacterium acnes-Induced Inflammatory Responses in a Mouse Ear Edema Model and Suppresses Pro-Inflammatory Chemokine Production via the MAPK and NF-κB Pathways in RAW264.7 Cells

Gao,

Xie,

Zhang

et al. 2023

Ann Dermatol

View full text Add to dashboard Cite

show abstract

“…When used two times a day for 3 months, it was efficient in treating these types of acne injuries, nevertheless, the additional experiments are necessary to strengthen its security and potency [34][35][36]. Dapsone 5% gel is a sulfone with antimicrobial and anti-inflammatory features [37,38]. The experiments established that topical dapsone gel 5% is efficient and harmless in minor-to-temperate acne vulgaris when used separately or in accumulation with other thematic agents [39,40].…”

Section: B Topical Retinoidsmentioning

confidence: 99%

Endocrine Disorders and Hormonal Therapy for Adolescent Acne

Assawaruangsin¹

2022

ijcsrr

View full text Add to dashboard Cite

Acne vulgaris is a worldwide disease which is mostly found in teenagers. This has a crucial impact on their life’s quality, particularly when endocrine disorders have been implicated. Current consideration regarding antibiotic stewardship, failing with antibiotic utilization, and the improvement of antibiotic-resistant Propionibacterium acnes, there are many treatment alternatives for pimple therapy have been acknowledged. A following analysis investigates hormonal treatments for the therapy of acne vulgaris.

show abstract

“…During puberty, an excess of male hormone can activate secretion of the sebaceous glands, and the epithelium of the hair follicles is complete and immature keratinization occurs, which is an abnormal keratinization called heterokeratosis [ 18 ]. Among the bacteria resident in hair follicles is Cutibacterium acnes , which secretes a lipolytic enzyme that decomposes triglycerides in sebum to form free fatty acids and stimulate hair follicles.…”

Section: Introductionmentioning

confidence: 99%