Dangerous Waters? Chronic Arsenic Exposure

Bhatt, Birju D.; Schaffer, Hal K.

doi:10.1016/j.amjmed.2017.08.016

Cited by 1 publication

(1 citation statement)

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“…3 Recent reservoirs of water are insufficient to fulfill the demands of the growing population and of course the clean water is a big issue side by side. 4 Due to lack of awareness and unavailability of water filtration systems, these toxins and heavy metals are freely incorporating and polluting the drinking water. 5 One of these contaminants is arsenic which has now gained a notable attention due to its increasing concentration in portable water.…”

Section: Introductionmentioning

confidence: 99%

Histomorphological Effects of Sodium Arsenite on Cervix of Rats: Experimental Study

Mir¹,

Butt²,

Yasmeen³

et al. 2021

PJMHS

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Arsenic contamination among heavy metals in ground water is a health hazard due to its toxicological concern, affecting millions of humans globally. Purpose: To observe and analyze the histomorphological effects of sodium arsenite on cervix of rat. Study Design: Laboratory based experimental study. Methodology: Present study held at department of anatomy, College of Physician and Surgeon Pakistan, Regional Centre Islamabad, in two principal groups, group A (control) and group B (experimental). The animals of B were administered sodium arsenite by oral gavage daily for 14 days while group A were administered only distilled water daily for 14 days. The animals of both groups were sacrificed after day 14th of drug administration. The cervix was processed for paraffin embedding and stained with Haematoxylin and Eosin (H&E). Statistical analysis: Data analyzed by SPSS 22.0v. Student’s t-test was applied to determine the significance. P-value ≤ 0.05 was considered significant. Results: The histological evaluation of experimental group animals showed decrease in cervical canal’s luminal area, hyperplasia of cervical epithelium and decrease thickness of cervical muscles. Conclusion: The nature of histomorphological effects observed in cervix showed that these changes may be due to oxidative stress produced by the formation of free radicals, decrease levels of serum estradiol, progesterone and by the denaturation of proteins. Key Words: Arsenic, Cervix, Free Radicals, Hyperplasia and Oxidative stress.

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Section: Introductionmentioning

confidence: 99%