Dammarane triterpenes from the resins of &lt;i&gt;Commiphora confusa&lt;/i&gt;

Dekebo, Aman; Dagne, Ermias; Curry, Pat; Gautun, Odd R.; Aasen, Arne J.

doi:10.4314/bcse.v16i1.20951

Cited by 12 publications

(9 citation statements)

References 11 publications

(16 reference statements)

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“…S3). Dammarane triterpenoids constitute the biggest group of Commiphora triterpenoids, and more than twenty-one dammarane triterpenoids have been found in the resins of four Commiphora species, including C. kua (Dekebo et al, 2002b;Manguro et al, 2003a), C. dalzieli (Waterman and Ampofo, 1985), C. confuse (Dekebo et al, 2002b;Manguro et al, 2003b) and C. myrrha (Shen et al, 2009). Polypodane triterpenoids from this genus are only discovered in the species of C. mukul (Kimura et al, 2001;Matsuda et al, 2004a,b).…”

Section: Triterpenoidsmentioning

confidence: 94%

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

Shen

Wang

et al. 2012

Journal of Ethnopharmacology

213

161

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Section: Triterpenoidsmentioning

confidence: 94%

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

Shen

Wang

et al. 2012

Journal of Ethnopharmacology

213

161

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“…The resin of Commiphora confusa afforded two new dammarane triterpenes, (3R,20S)-3,20-dihydroxydammar-24-ene 285 and (3R,20S)-3-acetoxy-20-hydroxydammar-24ene 286 along with the known triterpenes, cabraleadiol 3-acetate 236 and α-amyrin 287 (ref. 134 ).…”

Section: Compoundmentioning

confidence: 99%

Myrrh - Commiphora chemistry

Hanŭs¹,

Řezanka²,

Dembitsky³

et al. 2005

Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub

217

162

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Myrrh and opopanax has been used throughout history in incense and as a perfume. Since Bible times it has been used for the treatment of wounds. The first attempts to identify content compounds were almost 100 years ago. In this review we discuss the present state of knowledge in the chemistry of substances of Commiphora spp. General On this place we must mention the most known Commiphoras, namely Commiphora myrrha (Nees) Engl., true myrrh, officinal myrrh, Heera Bol tree; C. myrrha (Nees) Engler var molmol Engler (C. molmol Engl. ex Tschirch), Somalian myrrh; Commiphora abyssinica (Berg) Engler (syn. Commiphora madagascarensis Jacq.), Arabian myrrh, Abyssinian myrrh; Commiphora africana (A. Rich.) Engl., myrrh, African bdelium; Commiphora guidottii Chiov., sweet myrrh, habag-hady (name in Somalia);

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“…Additionally, the cytotoxicity of nordammarane triterpenes, such as vibusambucin A, 12β-hydroxy-3,15-dioxo-20,21,22-23,24,25,26,27octanordammarane, and hupehenol A against KB, HepG-2, LU-1, and MCF-7 cell lines has been reported [16]. The resins of C. confusa contain triterpenes of the dammarane type [17] with moderate cytotoxic activity against HepG2 [18]. From the resin of C. erlangeriana we have previously isolated polygamain-type lignans named erlangerin A, and erlangerin B, and two lignans related to podophyllotoxin, erlangerin C, and erlangerin D [19].…”

Section: Introductionmentioning

confidence: 99%

Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines

et al. 2020

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Myrrh, a resin derived from the damaged bark of Commiphora genus, has traditionally been used for treatment of various human diseases, such as amenorrhea, ache, tumors, fever, and stomach pains. In spite of this widespread use of the myrrh in Ethiopia, the pharmacological activity and chemical composition have not been studied in detail. A new tricyclic triterpene acid (3S,4S,14S,7E,17E,21Z)-3,30-dihydroxypodioda-7,17,21-trien-4-carboxylic acid (commafric A) has been isolated from a crude methanolic extract of Commiphora africana (A. Rich.) Engl. resin along with the known pentacyclic triterpene α-amyrin. The structure of commafric A was characterized using different spectroscopic techniques such as 1D and 2D NMR, IR, and VCD combined with computations. The anti-proliferative activity of both isolated compounds was evaluated using SRB based colorimetric cellular assay against four human cancer cell lines. Etoposide was used as a positive control. Commafric A showed significant anti-proliferative effects against non-small cell lung cancer (A549) with IC 50 values of 4.52 μg/ml. The pentacyclic triterpene α-amyrin showed a weak antiproliferative activity against A2780 (ovarian cancer), MIA-PaCa-2 (pancreatic cancer), and SNU638 (stomach cancer) cell lines tested with IC 50 values ranging 9.28 to 28.22 μg/ml. Commafric A possessed anti-proliferative activity against non-small cell lung cancer (A549), which suggests that commafric A has potential to be further optimized being a lead compound in the search for new drugs against cancer diseases.

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Dammarane triterpenes from the resins of <i>Commiphora confusa</i>

Abstract: ABSTRACT. The resin of Commiphora confusa afforded two new dammarane triterpenes, (3R,20S)-3,20-dihydroxydammar-24-ene and (3R,20S)-3-acetoxy-20-hydroxydammar-24-ene along with the known triterpenes, cabraleadiol 3-acetate and a-amyrin.

Cited by 12 publications

References 11 publications

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

The genus Commiphora: A review of its traditional uses, phytochemistry and pharmacology

Myrrh - Commiphora chemistry

Anti-proliferative activity of a novel tricyclic triterpenoid acid from Commiphora africana resin against four human cancer cell lines

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