Abstract:Epithelial damage leads to early reactive oxygen species (ROS) signaling that regulates sensory neuron regeneration and tissue repair. How the initial type of tissue injury influences early damage signaling and regenerative growth of sensory neurons remains unclear. Previously we reported that thermal injury triggers distinct early tissue responses in larval zebrafish. Here, we found that thermal but not mechanical injury impairs sensory neuron regeneration and function. Real-time imaging revealed an immediate… Show more
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