Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma

Holcomb, John B.; Jenkins, Don; Rhee, Peter; Johannigman, Jay A.; Mahoney, Peter F.; Mehta, Sumeru; Cox, Elizabeth; Gehrke, Michael J.; Beilman, Greg J.; Schreiber, Martin A.; Flaherty, Stephen; Grathwohl, Kurt W.; Spinella, Phillip C.; Perkins, Jeremy G.; Beekley, Alec C.; McMullin, Neil R.; Park, Myung S.; Gonzalez, Ernest A.; Wade, Charles E.; Dubick, Michael A.; Schwab, C. William; Moore, F A; Champion, Howard R.; Hoyt, David B.; Hess, John R.

doi:10.1097/ta.0b013e3180324124

Cited by 1,008 publications

(772 citation statements)

References 59 publications

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“…31,33,38,42 Early and increased plasma transfusion has the potential to effectively prevent or treat coagulopathy and shock by improving hemostasis and volume expansion. 10,37,38,42 Each unit of FFP in addition to coagulation factors contains 0.5 g of fibrinogen.…”

Section: Discussionmentioning

confidence: 99%

Effect of Plasma and Red Blood Cell Transfusions on Survival in Patients With Combat Related Traumatic Injuries

Spinella

Perkins

Grathwohl

et al. 2008

Journal of Trauma: Injury, Infection &Amp; Critical Care

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156

108

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Section: Discussionmentioning

confidence: 99%

Effect of Plasma and Red Blood Cell Transfusions on Survival in Patients With Combat Related Traumatic Injuries

Spinella

Perkins

Grathwohl

et al. 2008

Journal of Trauma: Injury, Infection &Amp; Critical Care

Self Cite

156

108

View full text Add to dashboard Cite

“…Therefore the transfusion protocols differed. Many studies have recommended large transfusions of RBC, FFP and platelets to critically injured patient to prevent and treat coagulopathy [18,19]. DIC could be associated with different types of cancers [20].…”

Section: Discussionmentioning

confidence: 99%

Blood Component Utilization for Disseminated Intravascular Coagulation (DIC) Cases with Respect to Underlying Condition

Gupte

Jhaveri

2015

Indian J Hematol Blood Transfus

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To understand transfusion requirement in DIC with respect to (wrt) underlying cause. Patients' details were analyzed using parameters like yearly requirement, hemoglobin (Hb) and blood components utilization wrt age, sex and cause of DIC. Total 1931 DIC cases from 167 hospitals received 21,153 blood units including whole blood, red cell concentrate fresh frozen plasma, random donor platelets, single donor platelets and cryoprecipitate from year 2001 to 2013. Significant risk of DIC was for females compared to males (p \ 0.0001). Whole blood utilization was 25.5 % in 2001 which reduced to 1.2 % in 2013. Mean ± SD Hb concentration was 8.6 ± 3.0 in females and 9.8 ± 3.2 g/dL in males. The lowest mean Hb was 7 g/dL in female DIC cases having malignancy. Septicemia was the major cause of DIC followed by obstetric complications. The highest requirement was for trauma associated with septicemia, requiring 35 units/case. Combination of two or more underlying causes for DIC increased the blood component requirement.

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“…8 Similarly, early and even preemptive correction of coagulopathy (e.g., through use of recombinant factor VIIa) in battlefield victims has been demonstrated to result in fewer transfusions with no increase in thrombosis, providing valuable information for civilians suffering gunshot injury. 9,10 More generally, many of the improvements in the quality of civilian traumatic care have followed advances made in major military conflicts. World War I, for example, marked the beginning of motorized ambulance evacuation of the wounded, a practice later translated to the civilian world.…”

mentioning

confidence: 99%

Does the Declining Lethality of Gunshot Injuries Mask a Rising Epidemic of Gun Violence in the United States?

2014

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Recent mass shootings in the U.S. have reignited the important public health debate concerning measures to decrease the epidemic of gun violence. Editorialists and gun lobbyists have criticized the recent focus on gun violence, arguing that gun-related homicide rates have been stable in the last decade. While true, data from the U.S. Centers for Disease Control and Prevention also demonstrate that although gun-related homicide rates were stable between 2002 and 2011, rates of violent gunshot injuries increased. These seemingly paradoxical trends may reflect the declining lethality of gunshot injuries brought about by surgical advances in the care of the patient with penetrating trauma. Focusing on gun-related homicide rates as a summary statistic of gun violence, rather than total violent gunshot injuries, can therefore misrepresent the rising epidemic of gun violence in the U.S.

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Damage Control Resuscitation: Directly Addressing the Early Coagulopathy of Trauma

Cited by 1,008 publications

References 59 publications

Effect of Plasma and Red Blood Cell Transfusions on Survival in Patients With Combat Related Traumatic Injuries

Effect of Plasma and Red Blood Cell Transfusions on Survival in Patients With Combat Related Traumatic Injuries

Blood Component Utilization for Disseminated Intravascular Coagulation (DIC) Cases with Respect to Underlying Condition

Does the Declining Lethality of Gunshot Injuries Mask a Rising Epidemic of Gun Violence in the United States?

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