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Cited by 50 publications
(35 citation statements)
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“…The main mechanism is that intracellular sensors recognize endogenous DAMPs, such as AGEs, to increase the production of cytokines, and induce the chronic inflammation. 22 We found that AGEs stimulation could induce the inflammation in HPDLCs for increased production of inflammatory cytokines (IL-1β). As the most intensely studied member of IL-1 family, IL-1β is essential to establish an effective host F I G U R E 1 Effect of AGEs on the expression of inflammatory cytokines (IL-6, IL-1β) and NLRs in HPDLCs.…”
Section: Discussionmentioning
confidence: 83%
See 1 more Smart Citation
“…The main mechanism is that intracellular sensors recognize endogenous DAMPs, such as AGEs, to increase the production of cytokines, and induce the chronic inflammation. 22 We found that AGEs stimulation could induce the inflammation in HPDLCs for increased production of inflammatory cytokines (IL-1β). As the most intensely studied member of IL-1 family, IL-1β is essential to establish an effective host F I G U R E 1 Effect of AGEs on the expression of inflammatory cytokines (IL-6, IL-1β) and NLRs in HPDLCs.…”
Section: Discussionmentioning
confidence: 83%
“…Diabetes is accompanied by chronic inflammation. The main mechanism is that intracellular sensors recognize endogenous DAMPs, such as AGEs, to increase the production of cytokines, and induce the chronic inflammation . We found that AGEs stimulation could induce the inflammation in HPDLCs for increased production of inflammatory cytokines (IL‐1β).…”
Section: Discussionmentioning
confidence: 89%
“…Furthermore, subsequent activation of the NLRP3 inflammasome, a multiprotein danger‐sensing platform consisting of NLRP3, the adaptor protein ASC (apoptosis‐associated speck‐like protein containing a caspase‐recruitment domain, also known as Pycard), and the cysteine protease caspase‐1, in infiltrating macrophages provides a link between adipose tissue inflammation and the development of insulin resistance via the production of proinflammatory cytokines, IL‐1β and IL‐18 . Multiple endogenous danger signals, such as certain metabolites, have been identified that result in the activation of the NLRP3 inflammasome . Recently, endocannabinoids (ECs), anandamide (AEA) and 2‐arachidonoylglycerol (2‐AG), were identified as important factors that induce the activation of the NLRP3 inflammasome in obesity and T2D …”
Section: Introductionmentioning
confidence: 99%
“…It is now appreciated that diabetes is not just a disease of high blood glucose but also a disease of deranged metabolism resulting in hyperglycemia and the production of numerous metabolites such as uric acid and free fatty acids (9). These metabolites trigger inflammation that damages susceptible tissues with a resulting loss of function (10).…”
mentioning
confidence: 99%