Dairy product consumption and development of cancer: an overview of reviews

Jeyaraman, Maya M.; Abou‐Setta, Ahmed M; Grant, Laurel; Farshidfar, Farnaz; Copstein, Leslie; Lys, Justin; Gottschalk, Tania; Desautels, Danielle; Czaykowski, Piotr; Pitz, Marshall; Zarychanski, Ryan

doi:10.1136/bmjopen-2018-023625

Cited by 24 publications

(17 citation statements)

References 59 publications

(64 reference statements)

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“…The association between saturated fat in dairy products and cancer risk is not clearly established, due to methodologic limitations of most studies [134]. A large U.S. population-based cohort study and meta-analysis found no link between total dairy consumption and risk of cancer or cancer mortality.…”

Section: Saturated Fatmentioning

confidence: 99%

Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence

Bojková

Winklewski

Wszędybył-Winklewska

2020

IJMS

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A high-fat diet (HFD) induces changes in gut microbiota leading to activation of pro-inflammatory pathways, and obesity, as a consequence of overnutrition, exacerbates inflammation, a known risk factor not only for cancer. However, experimental data showed that the composition of dietary fat has a greater impact on the pathogenesis of cancer than the total fat content in isocaloric diets. Similarly, human studies did not prove that a decrease in total fat intake is an effective strategy to combat cancer. Saturated fat has long been considered as harmful, but the current consensus is that moderate intake of saturated fatty acids (SFAs), including palmitic acid (PA), does not pose a health risk within a balanced diet. In regard to monounsaturated fat, plant sources are recommended. The consumption of plant monounsaturated fatty acids (MUFAs), particularly from olive oil, has been associated with lower cancer risk. Similarly, the replacement of animal MUFAs with plant MUFAs decreased cancer mortality. The impact of polyunsaturated fatty acids (PUFAs) on cancer risk depends on the ratio between ω-6 and ω-3 PUFAs. In vivo data showed stimulatory effects of ω-6 PUFAs on tumour growth while ω-3 PUFAs were protective, but the results of human studies were not as promising as indicated in preclinical reports. As for trans FAs (TFAs), experimental data mostly showed opposite effects of industrially produced and natural TFAs, with the latter being protective against cancer progression, but human data are mixed, and no clear conclusion can be made. Further studies are warranted to establish the role of FAs in the control of cell growth in order to find an effective strategy for cancer prevention/treatment.

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Section: Saturated Fatmentioning

confidence: 99%

Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence

Bojková

Winklewski

Wszędybył-Winklewska

2020

IJMS

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“…It was reported to have antioxidant ( Almasaudi et al, 2016 , Ait Abderrahim et al, 2017 ), anti-inflammatory and estrogenic effects ( Porcza et al, 2016 ), apoptotic, immunomodulatory, antiproliferative ( Jaganathan et al, 2015 ) and anticarcinogenic action ( Subramanian et al, 2016 ). Besides, consumption of milk or dairy products (butter and Yoghurt) is correlated with a reduced risk of numerous types of cancer ( Jeyaraman et al, 2019 ). These properties are attributed to the variety of components such as fat compounds, conjugated linoleic acid, and proteins such as casein and vitamins (A, B, C, D) which have been proved to have protective and/or anticarcinogenic properties ( Davoodi et al, 2013 ).…”

Section: Discussionmentioning

confidence: 99%

Ethnopharmacological study of herbal remedies used for the management of thyroid disorders in Algeria

Taïbi

Abderrahim

Helal

et al. 2021

Saudi Pharmaceutical Journal

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Traditional medicine is gaining an increasing importance in diseases management. Besides, thyroid disease is one of the common endocrine disorders spreading at high frequency worldwide. The present work is an ethnopharmacological study aiming to identify, document and analyze aromatic and medicinal plants used in Algerian traditional medicines for thyroid disorders management. Semi-structured interviews with 120 herbalists and traditional practitioners and rural dwellers were realized in eleven locations in Algeria throughout field studies achieved from June 2017 to July 2019. Results reveal the use of 63 medicinal plants belonging to 59 genera and 34 families. The most represented botanical families were Lamiaceae, Fabaceae, Apiaceae, Amaranthaceae and Asteraceae. However, the most cited plant species were Atriplex halimus L., Bunium incrassatum (Boiss.) Amo, Nigella sativa L., Aquilaria malaccensis Lam. and Saussurea costus (Falc.) Lipsch. These species are taken alone or in mixtures of two or more ingredients from different origins such as honey, olive oil, and goat milk. Our findings revealed new therapeutic uses of 60 medicinal plants that have not been previously reported for the treatment of thyroid in Algeria. This is the first study documenting the traditional uses based on herbal medicine for thyroid management in Algeria. Our findings are relevant in the search for novel drug discovery. Obviously, it is the time to increase effective scientific studies on mechanisms of action of these medicinal plants in order to validate their popular usages.

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“…Some studies found a positive association between dairy consumption and PDAC risk [155]. Other studies, some at specific locations, did not find any association [156][157][158][159]. Some early reports linked the kinds of fatty acids found in dairy products to increased cancer risk.…”

Section: Dairymentioning

confidence: 99%

Pancreatic Cancer (PDAC): Introduction of Evidence-Based Complementary Measures into Integrative Clinical Management

Jentzsch

Davis

Djamgoz

2020

Cancers

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The most common form of pancreatic cancer is pancreatic ductal adenocarcinoma (PDAC), which comprises some 85% of all cases. Currently, this is the fourth highest cause of cancer mortality worldwide and its incidence is rising steeply. Commonly applied clinical therapies offer limited chance of a lasting cure and the five-year survival rate is one of the lowest of the commonly occurring cancers. This review cultivates the hypothesis that the best management of PDAC would be possible by integrating ‘western’ clinical medicine with evidence-based complementary measures. Protecting the liver, where PDAC frequently first spreads, is also given some consideration. Overall, the complementary measures are divided into three groups: dietary factors, nutraceutical agents and lifestyle. In turn, dietary factors are considered as general conditioners, multi-factorial foodstuffs and specific compounds. The general conditioners are alkalinity, low-glycemic index and low-cholesterol. The multi-factorial foodstuffs comprise red meat, fish, fruit/vegetables, dairy, honey and coffee. The available evidence for the beneficial effects of the specific dietary and nutraceutical agents was considered at four levels (in order of prominence): clinical trials, meta-analyses, in vivo tests and in vitro studies. Thus, 9 specific agents were identified (6 dietary and 3 nutraceutical) as acceptable for integration with gemcitabine chemotherapy, the first-line treatment for pancreatic cancer. The specific dietary agents were the following: Vitamins A, C, D and E, genistein and curcumin. As nutraceutical compounds, propolis, triptolide and cannabidiol were accepted. The 9 complementary agents were sub-grouped into two with reference to the main ‘hallmarks of cancer’. Lifestyle factors covered obesity, diabetes, smoking, alcohol and exercise. An integrative treatment regimen was devised for the management of PDAC patients. This involved combining first-line gemcitabine chemotherapy with the two sub-groups of complementary agents alternately in weekly cycles. The review concludes that integrated management currently offers the best patient outcome. Opportunities to be investigated in the future include emerging modalities, precision medicine, the nerve input to tumors and, importantly, clinical trials.

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Dairy product consumption and development of cancer: an overview of reviews

Cited by 24 publications

References 59 publications

Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence

Dietary Fat and Cancer—Which Is Good, Which Is Bad, and the Body of Evidence

Ethnopharmacological study of herbal remedies used for the management of thyroid disorders in Algeria

Pancreatic Cancer (PDAC): Introduction of Evidence-Based Complementary Measures into Integrative Clinical Management

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