Daily Variations in Pineal Melatonin Concentrations in Inbred and Outbred Mice

Vivien-Rœls, B.; Малан, А.; Rettori, Marie-Claire; Delagrange, Philippe; Jeanniot, Jean-Philippe; Pévet, Paul

doi:10.1177/074873098129000228

Cited by 117 publications

(111 citation statements)

References 9 publications

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“…0.05; group-time interaction, p . 0.05; day-night difference for CD8 + CT6 versus CT14 comparison, *p , 0.03; group difference, **p , 0.01; group-time interaction, **p , 0.01. levels of this hormone (42), an effect of melatonin may explain the difference observed between the studies. Notably, these previous studies were all conducted under alternation of light and dark, that is, in conditions that make it impossible to distinguish between endogenous control (e.g., by the clock) and environment-driven daily variations.…”

Section: Discussionmentioning

confidence: 77%

Circadian Variation of the Response of T Cells to Antigen

Fortier¹,

Rooney²,

Dardente³

et al. 2011

The Journal of Immunology

153

171

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Circadian clocks regulate many important aspects of physiology, and their disturbance leads to various medical conditions. Circadian variations have been found in immune system variables, including daily rhythms in circulating WBC numbers and serum concentration of cytokines. However, control of immune functional responses by the circadian clock has remained relatively unexplored. In this study, we show that mouse lymph nodes exhibit rhythmic clock gene expression. T cells from lymph nodes collected over 24 h show a circadian variation in proliferation after stimulation via the TCR, which is blunted in Clock gene mutant mice. The tyrosine kinase ZAP70, which is just downstream of the TCR in the T cell activation pathway and crucial for T cell function, exhibits rhythmic protein expression. Lastly, mice immunized with OVA peptide-loaded dendritic cells in the day show a stronger specific T cell response than mice immunized at night. These data reveal circadian control of the Ag-specific immune response and a novel regulatory mode of T cell proliferation, and may provide clues for more efficient vaccination strategies.

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Section: Discussionmentioning

confidence: 77%

Circadian Variation of the Response of T Cells to Antigen

Fortier¹,

Rooney²,

Dardente³

et al. 2011

The Journal of Immunology

153

171

View full text Add to dashboard Cite

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“…The role of clock genes in regulating pineal gland rhythmicity has received little attention, mainly due to the fact that many of the mouse genetic models used to study the function of the molecular clock are maintained on genetic backgrounds carrying mutations in two key enzymes of melatonin synthesis, arylalkylamine N-acetyltransferase (AANAT) and hydroxyindole-O-methyltransferase (HIOMT), resulting in melatonin deficiency (Goto et al 1989, Roseboom et al 1998, Vivien-Roels et al 1998. Clock-D19 mutants (Vitaterna et al 1994) were back-crossed into a melatonin-proficient strain, showing that the Clock-D19 mutation leads to phase delays and dampening of the melatonin rhythm in constant darkness conditions while GC rhythms were completely abolished (Kennaway et al 2003(Kennaway et al , 2006.…”

Section: Scn-pineal Interactionmentioning

confidence: 99%

Interactions between endocrine and circadian systems

Tsang¹,

Barclay

Oster

2013

Journal of Molecular Endocrinology

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In most species, endogenous circadian clocks regulate 24-h rhythms of behavior and physiology. Clock disruption has been associated with decreased cognitive performance and increased propensity to develop obesity, diabetes, and cancer. Many hormonal factors show robust diurnal secretion rhythms, some of which are involved in mediating clock output from the brain to peripheral tissues. In this review, we describe the mechanisms of clock-hormone interaction in mammals, the contribution of different tissue oscillators to hormonal regulation, and how changes in circadian timing impinge on endocrine signalling and downstream processes. We further summarize recent findings suggesting that hormonal signals may feed back on circadian regulation and how this crosstalk interferes with physiological and metabolic homeostasis.

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“…After isofluorane anesthesia and decapitation, brains and pineal glands were removed and stored at Ϫ80°C. Pineal melatonin content was determined by radioimmunoassay, as described previously (Vivien-Roels et al, 1999). In situ hybridization with riboprobes for Per1 and Per2 was performed as above on hypothalamic slices.…”

Section: Methodsmentioning

confidence: 99%

Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle

Mendoza¹,

Graff²,

Dardente³

et al. 2005

J. Neurosci.

191

173

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The suprachiasmatic nuclei (SCN) of the hypothalamus contain the master mammalian circadian clock, which is mainly reset by light. Temporal restricted feeding, a potent synchronizer of peripheral oscillators, has only weak influence on light-entrained rhythms via the SCN, unless restricted feeding is coupled with calorie restriction, thereby altering phase angle of photic synchronization. Effects of daytime restricted feeding were investigated on the mouse circadian system. Normocaloric feeding at midday led to a predominantly diurnal (60%) food intake and decreased blood glucose in the afternoon, but it did not affect the phase of locomotor activity rhythm or vasopressin expression in the SCN. In contrast, hypocaloric feeding at midday led to 2-4 h phase advances of three circadian outputs, locomotor activity rhythm, pineal melatonin, and vasopressin mRNA cycle in the SCN, and it decreased daily levels of blood glucose. Furthermore, Per1 and Cry2 oscillations in the SCN were phase advanced by 1 and 3 h, respectively, in hypocalorie-but not in normocalorie-fed mice. The phase of Per2 and Bmal1 expression remained unchanged regardless of feeding condition. Moreover, the shape of behavioral phase-response curve to light and light-induced expression of Per1 in the SCN were markedly modified in hypocalorie-fed mice compared with animals fed ad libitum. The present study shows that diurnal hypocaloric feeding affects not only the temporal organization of the SCN clockwork and circadian outputs in mice under light/dark cycle but also photic responses of the circadian system, thus indicating that energy metabolism modulates circadian rhythmicity and gating of photic inputs in mammals.

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Daily Variations in Pineal Melatonin Concentrations in Inbred and Outbred Mice

Cited by 117 publications

References 9 publications

Circadian Variation of the Response of T Cells to Antigen

Circadian Variation of the Response of T Cells to Antigen

Interactions between endocrine and circadian systems

Feeding Cues Alter Clock Gene Oscillations and Photic Responses in the Suprachiasmatic Nuclei of Mice Exposed to a Light/Dark Cycle

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