Daily use of dentifrice with and without xylitol and fluoride: effect on glucose retention in humans in vivo

Iwata, Chikayoshi; Nakagaki, Haruo; Morita, Ichizo; Sekiya, Toshiko; Goshima, Miho; Abe, Toshiyuki; Isogai, A; Hanaki, Masahiro; Kuwahara, Miyoko; Tatematsu, Masashi; Robinson, C.

doi:10.1016/s0003-9969(03)00033-5

Cited by 10 publications

(5 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2022; 22:e210046 observed, as in probiotic formulations [74]. Furthermore, other products, also related to dentistry, showed a combination of xylitol and sorbitol or fluoride to control dental biofilm, white spot lesions and improve salivary parameters [23,30,[75][76][77][78][79][80][81]. However, there was no statistical difference between studies regarding the effect of products with isolated xylitol compared to xylitol associated with other active compounds in the present review.…”

Section: Discussionmentioning

confidence: 80%

See 1 more Smart Citation

The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials

Martins

Leite

Magno

et al. 2022

Pesqui. Bras. Odontopediatria Clín. Integr.

View full text Add to dashboard Cite

Objective: To describe and evaluate the xylitol products' applicability and its effects in the health area worldwide utilizing a bibliometric analysis from randomized controlled trials (RCT) with humans. Material and Methods: Electronic searches were carried out in Medline/PubMed, Scopus, Cochrane Library, Web of Science, and VHL databases. The main data extracted were: year, area of applicability, type of treatment, country, journal, xylitol posology and concentration, presentation form, outcomes, and effects. Results: From 1476 studies, 257 were included. These studies were published between 1973-2021. The majority was carried out in dentistry (73.9%) and under preventive treatment (67.4%). These studies were developed in the USA (15.4%) and published in Caries Research (6.6%). The posology and concentration ranged between 0.004-67 g/day and 0.002-100%, respectively. The xylitol is usually used in the chewing gum form (44.0%), and for antimicrobial activity evaluation (38.5%). A positive effect was observed in 204 studies (79.3%) and was associated with xylitol concentration ≥ 15% (p=0.007). Side effects were reported in 8.2% and were associated with posology ≥ 5 g/day (p=0.03). Conclusion: Most studies with xylitol were conducted to prevent diseases in the dentistry field. The chewing gum form and antimicrobial activity evaluation were more frequent. Most xylitol products have a positive effect, and few studies report side effects.

show abstract

Section: Discussionmentioning

confidence: 80%

“…Xylitol has also been used to regulate blood glucose levels, as this sucrose substitute has a low absorption rate in the gastrointestinal tract [1,13,32,75]. For the same reason, xylitol can be used for gastric emptying [7,12,40,68,91].…”

Section: Discussionmentioning

confidence: 99%

The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials

Martins

Leite

Magno

et al. 2022

Pesqui. Bras. Odontopediatria Clín. Integr.

View full text Add to dashboard Cite

show abstract

“…All these factors increase the amount of soluble calcium in dental plaque, which in turn facilitates remineralization of the enamel. 8 Today, more than 50% of chewing gums and candies are sweetened with xylitol. One major obstacle with the use of both gums and candies for xylitol administration is high frequency and the rather large number of pellets that are required to deliver the therapeutic amounts.…”

Section: Introductionmentioning

confidence: 99%

Effect of dentifrices containing sorbitol, combination of xylitol and sorbitol on salivary Streptococcus mutans and Lactobacillus counts in 14-15 year old children: a randomized trial

Shwetha

Vivek

2017

Int J Clin Trials

View full text Add to dashboard Cite

Background: Xylitol, a naturally occurring sugar alcohol which cannot be fermented by oral microorganisms has been shown to reduce Streptococcus mutans levels in plaque and saliva and to markedly reduce tooth decay. Studies have proved that combination of xylitol and sorbitol added in chewing gum is more effective in reducing tooth decay compared to xylitol alone. Purpose of this double blinded, parallel, randomized trial was to compare the relative effect of sorbitol and combination of xylitol and sorbitol containing dentifrices on salivary Streptococcus mutans and Lactobacillus in a group of high school children.Methods: Sixty school children with age group of 14-15 years were randomly allocated into 2 study groups (S-sorbitol containing dentifrice and X+S- Xylitol and Sorbitol containing dentifrice), with 32 participants in each group. Subjects were asked to use the experimental dentifrices twice daily for 3 months period. Resting whole saliva was collected at baseline, at the end of 1 month, 2 months and 3 months interval after the use of assigned dentifrice. Saliva samples were used for microbial analysis. Streptococcus mutans was cultured on Mitis salivarius bacitracin agar and Lactobacilli on Rogosa SL agars. Results were expressed in frequencies. Nonparametric tests namely Wilcoxons-signed rank test and Mann Whitney U test were used for testing the statistical significance. The level of significance was set at p=0.05.Results: There was no significant difference in salivary Streptococcus mutans count amongst the two groups at baseline (p=0.271). There was no significant difference in counts of Streptococcus mutans and lactobacilli among the subjects in the sorbitol containing dentifrices (S) group at different time intervals of the study whereas there was significant reduction in counts of Streptococcus mutans and Lactobacillus count among the subjects in the xylitol and sorbitol (X+S) containing dentifrices at all the time interval. At the end of 3rd month interval there was significantly low Streptococcous mutans and lactobacilli count for X+S group compared to S group with p<0.001 and p=0.02 respectively. Conclusions: The use of dentifrices containing combination of xylitol and sorbitol, twice daily showed significant antimicrobial properties against salivary Streptococcus mutans and lactobacillus by the end of 3 month compared to sorbitol containing dentifrice.

show abstract

“…Entretanto, o principal inconveniente do uso de ácido sulfúrico é permitir a promoção por este da degradação da glicose em função das altas temperaturas, requeridas para a hidrólise da celulose (BIENKOWSKI et al, 1987;SAEMAN, 1945 propriedades laxantes e, se consumido em grandes quantidades, pode causar diarréia osmótica (CURTAYRES, 1980;DUFFY;ANDERSON, 1998;EMODI, 1978;GRENBY;COLLEY, 1983;MÄKINEN, 2000 (IWATA et al, 2003;MÄKINEN, 1979;MÄKINEN, 2000;NOTHENBERG, 1994). Por outro lado, segundo Mäkinen (1979) (FUNK, 1975;MÄKINEN, 2000).…”

Section: Lignocelulósicosunclassified

Estudo de viabilidade econômica da produção de xilitol a partir de hidrolisado hemicelulósico de palha de cevada

Moraes¹

View full text Add to dashboard Cite

Daily use of dentifrice with and without xylitol and fluoride: effect on glucose retention in humans in vivo

Cited by 10 publications

References 19 publications

The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials

The Xylitol Applicability and its Effects in Health Area Worldwide: A Bibliometric Analysis Based on Randomized Controlled Trials

Effect of dentifrices containing sorbitol, combination of xylitol and sorbitol on salivary Streptococcus mutans and Lactobacillus counts in 14-15 year old children: a randomized trial

Estudo de viabilidade econômica da produção de xilitol a partir de hidrolisado hemicelulósico de palha de cevada

Contact Info

Product

Resources

About