Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice

Cheong, Sun Hee; Furuhashi, Keisuke; Ito, Katsuki; Nagaoka, Masato; Yonezawa, Takayuki; Miura, Yutaka; Yagasaki, Kazumi

doi:10.1016/j.jnutbio.2013.09.012

Cited by 92 publications

(68 citation statements)

References 42 publications

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“…The authors propose a direct effect of phytoestrogens on adipose tissue through ERα (Hwang et al, 2005), as in vitro exposure of 3T3-L1 adipocytes to genistein has been reported to significantly activate AMPK. Other studies propose a similar effect of phytoestrogens in muscle cells, with increased insulin-stimulated IRS-1/PI3K/Akt pathway mediated by reduced phosphorylation of IRS-1 through AMPK activation and S6K1 inhibition (Arunkumar and Anuradha, 2012;Cheong et al, 2014).…”

Section: Discussionmentioning

confidence: 80%

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Andreoli

Stoker

Rossetti

et al. 2015

Molecular and Cellular Endocrinology

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A B S T R A C TThe absence of phytoestrogens in the diet during pregnancy has been reported to result in obesity later in adulthood. We investigated whether phytoestrogen withdrawal in adult life could alter the hypothalamic signals that regulate food intake and affect body weight and glucose homeostasis.Male Wistar rats fed from conception to adulthood with a high phytoestrogen diet were submitted to phytoestrogen withdrawal by feeding a low phytoestrogen diet, or a high phytoestrogen-high fat diet. Withdrawal of dietary phytoestrogens increased body weight, adiposity and energy intake through an orexigenic hypothalamic response characterized by upregulation of AGRP and downregulation of POMC. This was associated with elevated leptin and T4, reduced TSH, testosterone and estradiol, and diminished hypothalamic ERα expression, concomitant with alterations in glucose tolerance.Removing dietary phytoestrogens caused manifestations of obesity and diabetes that were more pronounced than those induced by the high phytoestrogen-high fat diet intake.

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Section: Discussionmentioning

confidence: 80%

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Andreoli

Stoker

Rossetti

et al. 2015

Molecular and Cellular Endocrinology

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“…However, smaller sample size, and lower levels of soy consumption may have hampered the ability to detect effects of soy consumption in AA. The soy isoflavone genistein has been found to protect against cytokine-mediated dysfunction of pancreatic beta cells[29], while daidzein has been found to promote glucose uptake and reduce cytokine expression[30], suggesting that soy consumption may protect against inflammation-induced insulin resistance in humans through modulation of cytokine signaling[31]. …”

Section: Discussionmentioning

confidence: 99%

Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers

Ferguson¹,

Ryan²,

Gibney³

et al. 2014

Nutrition, Metabolism and Cardiovascular Diseases

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Background and Aims Consumption of foods that modulate inflammatory stress in genetically-prone individuals may influence development of cardiometabolic diseases. Isoflavones in soy-derived foods function as phytoestrogens, have antioxidant and anti-inflammatory activity, inhibit protein-tyrosine kinase activity, and may be atheroprotective. We examined the relationship between soy food consumption and inflammatory responses to endotoxemia, postprandial responses to oral lipid tolerance test (OLTT), and insulin sensitivity from frequently sampled intravenous tolerance tests (FSIGTT). Methods and Results We administered low-dose endotoxin (LPS 1 ng/kg) to induce transient endotoxemia in young, healthy volunteers (N=215) of African (AA), and European (EA) ancestry as part of the GENE Study. We further supported these findings in two independent samples: the MECHE Study and NHANES. Soy food consumption was a significant predictor of peak cytokine response following LPS. Individuals with moderate-high (>1.48mg/day, N=65) vs. low-no (<1.48mg/day, N=150) isoflavone consumption had significantly higher tumor necrosis factor alpha (TNFα) post-LPS (AUC, P=0.009). Further, high-isoflavone consumers were protected against inflammation-induced decline in insulin sensitivity (SI) in GENE. We observed significant differences by soy consumption in the interferon gamma (IFNγ) response to OLTT, and the insulin response to OGTT in MECHE, as well as significantly lower fasting insulin, and 2-hour glucose post-OGTT in EA NHANES subjects. Conclusion We demonstrate that soy consumption may influence inflammatory and metabolic responses. In research of nutritional exposures, measuring evoked phenotypes may be more informative than describing resting characteristics. Clinical Trial Registry The GENE Study was registered under NCT00953667 and the MECHE Study under NCT01172951, both at clinicaltrials.gov.

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“…[227][228][229][230][231][232][233][234] Due to their limited bioavailability through high hydrophobicity, nanolipid carrier-based technologies have been recently used to improve the bioavailability for oral delivery. A lipid-based nanodelivery approach was recently developed to improve the effect of daidzein through oral delivery, and the daidzein-loaded lipid carrier was found to have a 6.8 times increase in bioavailability.…”

Section: Nano-daidzeinmentioning

confidence: 99%

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

Ganesan¹,

Arulselvan²,

Choi³

2017

IJN

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Type 2 diabetes mellitus (T2DM) is a major chronic disease that is prevalent worldwide, and it is characterized by an increase in blood glucose, disturbances in the metabolism, and alteration in insulin secretion. Nowadays, food-based therapy has become an important treatment mode for type 2 diabetes, and phytobioactive compounds have gained an increasing amount of attention to this end because they have an effect on multiple biological functions, including the sustained secretion of insulin and regeneration of pancreatic islets cells. However, the poor solubility and lower permeability of these phyto products results in a loss of bioactivity during processing and oral delivery, leading to a significant reduction in the bioavailability of phytobioactive compounds to treat T2DM. Recently, nanotechnological systems have been developed for use as various types of carrier systems to improve the delivery of bioactive compounds and thus obtain a greater bioavailability. Furthermore, carrier systems in most nanodelivery systems are highly biocompatible, with nonimmunologic behavior, a high degree of biodegradability, and greater mucoadhesive strength. Therefore, this review focuses on the various types of nanodelivery systems that can be used for phytobioactive compounds in treating T2DM with greater antidiabetic effects. There is also additional focus on improving the effects of various phytobioactive compounds through nanotechnological delivery to ensure a highly efficient treatment of type 2 diabetes.

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Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice

Cited by 92 publications

References 42 publications

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status

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Daidzein promotes glucose uptake through glucose transporter 4 translocation to plasma membrane in L6 myocytes and improves glucose homeostasis in Type 2 diabetic model mice

Cited by 92 publications

References 42 publications

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Withdrawal of dietary phytoestrogens in adult male rats affects hypothalamic regulation of food intake, induces obesity and alters glucose metabolism

Dietary isoflavone intake is associated with evoked responses to inflammatory cardiometabolic stimuli and improved glucose homeostasis in healthy volunteers

Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus &ndash; current status

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Phytobioactive compound-based nanodelivery systems for the treatment of type 2 diabetes mellitus – current status