Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
9
0

Year Published

2017
2017
2021
2021

Publication Types

Select...
2
1

Relationship

0
3

Authors

Journals

citations
Cited by 6 publications
(9 citation statements)
references
References 9 publications
(11 reference statements)
0
9
0
Order By: Relevance
“…elegans , WormExp 31 ; a high-quality protein-DNA interaction network 32 ; and two databases of miRNA-target interactions: the in silico predicted TargetScan 33 and the experimentally validated MirTarBase 34 . Enrichment analysis of the list detected ten hits already experimentally characterised as regulators of aging: DAF-16 35 , ELT-2 36 , ELT-6 37 , PMK-1 38,39 , PQM-1 40 , NHR-1, NHR-10, NHR-86 41 , let -7 42,43 , and miR-60 44 .…”
Section: Resultsmentioning
confidence: 99%
“…elegans , WormExp 31 ; a high-quality protein-DNA interaction network 32 ; and two databases of miRNA-target interactions: the in silico predicted TargetScan 33 and the experimentally validated MirTarBase 34 . Enrichment analysis of the list detected ten hits already experimentally characterised as regulators of aging: DAF-16 35 , ELT-2 36 , ELT-6 37 , PMK-1 38,39 , PQM-1 40 , NHR-1, NHR-10, NHR-86 41 , let -7 42,43 , and miR-60 44 .…”
Section: Resultsmentioning
confidence: 99%
“…We further employed the Worm Exp tool (https://wormexp.zoologie.uni-kiel.de/wormexp/) (Yang et al, 2016) to analyze the age determination genes to identify specific pathways that could be transcriptionally regulated by PITX/UNC-30. We found that the SKN-1, MDL-1, and PQM-1 age determination pathways were highly enriched (Figure 2D and Table S4) (Riesen et al, 2014; Tepper et al, 2013a; Tepper et al, 2014; Tullet et al, 2008). Although the SKN-1 cluster had the highest representation factor (Figure 2D), most of the genes up-regulated in unc-30(ok613) animals were under the control of the MDL-1 pathway (Figure 2E).…”
Section: Resultsmentioning
confidence: 96%
“…Although the SKN-1 cluster had the highest representation factor (Figure 2D), most of the genes up-regulated in unc-30(ok613) animals were under the control of the MDL-1 pathway (Figure 2E). Because the evolutionarily conserved transcription factors, MDL-1 and PQM-1 are known to suppress longevity and their inactivation results in lifespan extension (Riesen et al, 2014; Tepper et al, 2013b; Tepper et al, 2014), the upregulation of MDL-1 and PQM-1-dependent genes in unc-30(ok613) animals could explain the reduced longevity of the animals. We confirmed the role of PITX/UNC-30 in the control of MDL-1 and PQM-1-dependent genes (Figure 2F).…”
Section: Resultsmentioning
confidence: 99%
See 1 more Smart Citation
“…We found enrichment for genes encoding protein targets of PMK-1 (p38 mitogen-activated protein kinase, a regulator of the innate immune response), reported to contribute to longevity and immunosenescence [35,45], and PQM-1, a stress-response transcription factor that interacts antagonistically with DAF-16, recently characterized as an important lifespan regulator [46].…”
Section: Targets Of Transcription Factors or Rna Binding Proteinsmentioning
confidence: 98%