volume 93, issue 0, P3-O-131 2020
DOI: 10.1254/jpssuppl.93.0_3-o-131
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Abstract: Background] Cardiomyocyte (CM) death causes the loss of CMs, resulting in heart failure. Therefore, the prevention of CM death could be a therapeutic strategy against heart failure. Defender against cell death 1 (Dad1) was reported to play anti-apoptotic roles in neural cells. Though Dad1 is highly expressed in heart, the functional roles of Dad1 remain to be elucidated. Previously, we reported that the knockdown of Dad1 induced CM death. The aim of this study is to elucidate the cytoprotective mechanism of Da…

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