2002
DOI: 10.1177/154411130201300206
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Abstract: ABSTRACT:This review aims at discussing the pathogenesis of enamel fluorosis in relation to a putative linkage among ameloblastic activities, secreted enamel matrix proteins and multiple proteases, growing enamel crystals, and fluid composition, including calcium and fluoride ions. Fluoride is the most important caries-preventive agent in dentistry. In the last two decades, increasing fluoride exposure in various forms and vehicles is most likely the explanation for an increase in the prevalence of mild-to-mod… Show more

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Cited by 387 publications
(322 citation statements)
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“…About half of the absorbed F − is quickly incorporated into developing bone and teeth, where nearly all of the body's F − is found, and the remainder is excreted in the urine (Cerklewski, 1997). Exposure to F − during enamel development causes a dose-related disruption of enamel mineralization resulting in anomalously large gaps in its crystalline structure, excessive retention of enamel proteins, and increased porosity of the teeth (Aoba and Fejerskov, 2002). The high prevalence of DF found in the study population is understandable: 89.9% of them live in communities having groundwater with F − concentration exceeding the WHO standard (N1.5 mg/l), and approximately 2/3 of these residents source water for drinking and cooking from the boreholes and dug wells which have the highest levels of naturally occurring chemical contaminants.…”
Section: Discussionmentioning
confidence: 99%
“…About half of the absorbed F − is quickly incorporated into developing bone and teeth, where nearly all of the body's F − is found, and the remainder is excreted in the urine (Cerklewski, 1997). Exposure to F − during enamel development causes a dose-related disruption of enamel mineralization resulting in anomalously large gaps in its crystalline structure, excessive retention of enamel proteins, and increased porosity of the teeth (Aoba and Fejerskov, 2002). The high prevalence of DF found in the study population is understandable: 89.9% of them live in communities having groundwater with F − concentration exceeding the WHO standard (N1.5 mg/l), and approximately 2/3 of these residents source water for drinking and cooking from the boreholes and dug wells which have the highest levels of naturally occurring chemical contaminants.…”
Section: Discussionmentioning
confidence: 99%
“…However, when fluoride is ingested during enamel mineralization, dental fluorosis can develop. 15 Thus, an adequate concentration of F in drinking water is necessary for water fluoridation to reach its maximum anticaries benefit with a minimum risk of fluorosis. 11 Data from this study showed that 83.7% of all of the water samples analyzed were within the range of best benefit and least risk, considering the new classification proposed by CECOL/USP.…”
Section: Discussionmentioning
confidence: 99%
“…Dental fluorosis is a result of excessive fluoride ingestion during enamel development, which for the permanent teeth occurs in childhood between 2 to 8 years old 27 . The use of fluoride in preventive dentistry has been the most effective in carious lesions, but it also associated with the increasing prevalence of dental fluorosis in many countries.…”
Section: Discussionmentioning
confidence: 99%