Cytotoxicity of glucosone in the presence of cupric ion

Nakayama, Tsutomu; Terazawa, Kaoru; Kawakishi, Shunrô

doi:10.1021/jf00017a024

Cited by 10 publications

(3 citation statements)

References 14 publications

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“…In a previous study (9), glucosone decreased the survival of V79 cells in cubated under HEPES buffered saline (HBS) for 30min only in the presence of Cu2+ among seven kinds of metal ions. Hence, Cu2+ in the medium seemed to be essential under those experimental conditions.…”

Section: Discussionmentioning

confidence: 88%

Role of Active Oxygen Species in the Toxic Effects of Glucosone on Mammalian Cells.

Nakayama

Terazawa

Kawakishi

1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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SummaryGlucosone (D-arabino-hexos-2-ulose), a typical enediol prod uct formed both in the Maillard reaction and Tradiolysis of sugars, decreased survival of Chinese hamster lung V79 cells, which were in cubated under MEM for 4h. Inhibition of the decrease in cell servival by catalase and SOD suggests the role of active oxygen species, namely H2O2 and O2-, in the biological effects of glucosone. H2O2 was formed in the medium during oxidative degradation of glucosone. Inhibition of the formation of H2O2 by SOD indicates that the formation of H2O2 and the consequent decrease of the cell survival was enhanced by O2-. These results suggest that the mechanisms of the effects of glucosone on the mammalian cells in the absence of Cu2+ are different from those in the presence of Cu2+.

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Section: Discussionmentioning

confidence: 88%

Role of Active Oxygen Species in the Toxic Effects of Glucosone on Mammalian Cells.

Nakayama

Terazawa

Kawakishi

1992

Journal of Nutritional Science and Vitaminology, J Nutr Sci Vit

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“…[19] For instance, the importance of copper in human metabolism is its involvement in oxidative processes. [20][21][22][23][24][25] Aluminum was chosen due to its high presence in the environment and extensive use in modern daily life (diets and medication). However, there is no known physiological role for aluminum within the body and hence this metal may strongly alter normal cellular metabolic pathways and produce adverse physiological effects.…”

Section: Introductionmentioning

confidence: 99%

Metal-Binding Ability of Leu-Enkephalin, Related Glycoconjugates and Peptidomimetics

Májer¹,

Vass²,

Roščić³

et al. 2015

Croat. Chem. Acta

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Abstract:Both the chemistry and consequences of the nonenzymatic reaction between reducing sugars and reactive amino groups of amino acids, peptides and proteins (known as the Maillard reaction), have received considerable attention in food and health science fields. This initial reaction results in Amadori and similar products formation, followed by degradation to advanced glycation end products (AGEs). It is well established that AGEs are associated with color and odor of thermally processed or stored food, as well as with pathogen products in a number of diseases. The model systems of early stage Maillard reaction products (MRP) were prepared between endogenous opioid peptide leucine enkephalin (1) and D-glucose / D-glucuronic acid. The complexation ability of prepared MRP with metal ions (Ca 2+ , Zn 2+ , Al 3+ , Pb 2+ and Cu 2+ ) was investigated and compared to the complexation ability of parent peptide using ECD and FTIR spectroscopic measurements.

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“…Enolization of Amadori compounds (1-amino-1-deoxy-2-ketose derivatives) usually formed in this process is thought to play an important role, contributing to the generation of oxygen free radicals, and their subsequent oxidative damage to proteins [8]. Particularly, copper(II) ions were verified to markedly increase the rate of those oxidative processes [9][10][11].…”

Section: Introductionmentioning

confidence: 99%

Kinetic studies of carbohydrate oxidation catalyzed by novel isatin–Schiff base copper(II) complexes

Cerchiaro

Micke

Tavares

et al. 2004

Journal of Molecular Catalysis A: Chemical

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Cytotoxicity of glucosone in the presence of cupric ion

Cited by 10 publications

References 14 publications

Role of Active Oxygen Species in the Toxic Effects of Glucosone on Mammalian Cells.

Role of Active Oxygen Species in the Toxic Effects of Glucosone on Mammalian Cells.

Metal-Binding Ability of Leu-Enkephalin, Related Glycoconjugates and Peptidomimetics

Kinetic studies of carbohydrate oxidation catalyzed by novel isatin–Schiff base copper(II) complexes

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