Cytotoxicity and slow release of the anti-cancer drug doxorubicin from ZIF-8

Vasconcelos, Iane B.; Silva, Teresinha G. da; Militão, Gardênia Carmen Gadelha; Soares, Thereza A.; Rodrigues, Nailton M.; Rodrigues, Marcelo O.; Costa, Nivan B. da; Freire, Ricardo O.; Severino, Andrea

doi:10.1039/c2ra21087h

Cited by 267 publications

(165 citation statements)

References 49 publications

(81 reference statements)

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“…In this study, the doxorubicin: ZIF-8 complex, which aims to treat mucoepidermoid carcinoma of human lung, human colorectal adenocarcinoma (HT-29) and human promyelocytic leukaemia (HL-60) cell lines, exhibits lower toxicity than pure doxorubicin, probably due to the slow release of the drug that is achieved with this complex (Figure 6) [69,104]. Furthermore, ZIF-8 crystals loaded with doxorubicin proved to be efficient pH-responsive drug delivery systems, in which the drug is released in a controlled manner at low pH (5.0-6.5).…”

Section: Slow Release Of the Anti-cancer Drug Doxorubicin From Zif-8mentioning

confidence: 99%

“…ZIFs simultaneously have the following characteristics of MOFs and zeolites, combining the advantages of both: ultrahigh surface areas, unimodal micropores, high crystallinity, various functionalities and exceptional thermal and chemical stabilities, making them very promising for biomedical applications [63,64]. Several studies describe the successful incorporation of anticancer drugs into ZIF-8 with positive results for the controlled pH-sensitive drug release and fluorescence imaging [65][66][67][68][69]. Also caffeine was already encapsulated into ZIF-8 showing a controlled release [70,71].…”

Section: Introductionmentioning

confidence: 99%

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Bio-Inspired Metal-Organic Frameworks in the Pharmaceutical World: A Brief Review

André¹,

Quaresma²

2016

Metal-Organic Frameworks

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One of the great challenges in the pharmaceutical industry is the search for more efficient and cost-effective ways to store and deliver existing drugs. Bio-inspired metalorganic frameworks (BioMOFs) are groundbreaking materials that have recently been explored for drug storage, delivery and controlled release as well as for applications in imaging and sensing for therapeutic and diagnostic. This review presents a brief overview on these materials, and by alluding to a few reported examples, it intends to clearly show the extremely important role that BioMOFs have been playing in the pharmaceutical field.

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Section: Slow Release Of the Anti-cancer Drug Doxorubicin From Zif-8mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Bio-Inspired Metal-Organic Frameworks in the Pharmaceutical World: A Brief Review

André¹,

Quaresma²

2016

Metal-Organic Frameworks

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“…This increases drug concentration at the target site and is expected to be a more efficient technique than the standard methods of drug delivery. Doxorubicin (DoX) is a low molecular weight, anthracycline drug which is effective against a wide range of malignant conditions, especially lukemia and lymphoma, as well as cancers of bladder, breast, stomach, lung and ovaries [9,10]. However, the drug possesses a cumulative dose-dependent cardiotoxicity and can lead to drug-induced congestive heart failure [10,11].…”

Section: Introductionmentioning

confidence: 99%

“…Doxorubicin (DoX) is a low molecular weight, anthracycline drug which is effective against a wide range of malignant conditions, especially lukemia and lymphoma, as well as cancers of bladder, breast, stomach, lung and ovaries [9,10]. However, the drug possesses a cumulative dose-dependent cardiotoxicity and can lead to drug-induced congestive heart failure [10,11]. Controlling or reducing the dose of DoX is known to prevent the significant risk factors enabling its use for long term chemotherapy [9].…”

Section: Introductionmentioning

confidence: 99%

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Khalid

Mitropoulos

Marelli

et al. 2015

Biomed. Opt. Express

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Nanoparticle (NP) based technologies have proved to be considerably beneficial for advances in biomedicine especially in the areas of disease detection, drug delivery and bioimaging. Over the last few decades, NPs have garnered interest for their exemplary impacts on the detection, treatment, and prevention of cancer. The full potential of these technologies are yet to be employed for clinical use. The ongoing research and development in this field demands single multifunctional composite materials that can be employed simultaneously for drug delivery and biomedical imaging. In this manuscript, a unique combination of silk fibroin (SF) and nanodiamonds (NDs) in the form of nanospheres are fabricated and investigated. The spheres were loaded with the anthracyline Doxorubicin (DoX) and the drug release kinetics for these ND-SF-DoX (NDSX) spheres were studied. NDs provided the fluorescence modality for imaging while the degradable SF spheres stabilized and released the drug in a controlled manner. The emission and structural properties of the spheres were characterized during drug release. The degradability of SF and the subsequent release of DoX from the spheres were monitored through fluorescence of NDs inside the spheres. This research demonstrates the enormous potential of the ND-SF nanocomposite platforms for diagnostic and therapeutic purposes, which are both important for pharmaceutical research and clinical settings. "Nanodiamond-mediated drug delivery and imaging: challenges and opportunities," Expert Opin. Drug Deliv. 12(5), 735-749 (2015).

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“…The ZnBDC framework kept the same crystal structure before and after contact with the Gen solution for a time period of up to 7 days ( Figure S4, SI section). 28,57 Conversely, the XRD patterns for ZIF-8 before and after contact with Gen shows alterations ( Figure S5, SI section), which may indicate drug adsorption to the framework (see further discussion of the TGA data below). The XRD patterns of the frameworks present thin peaks, indicating high crystallinity and in good agreement with previous studies reported in the literature.…”

mentioning

confidence: 99%

Metal Organic Frameworks for Selective Degradation of Amoxicillin in Biomedical Wastes

Paula

Barros

Wanderley

et al. 2018

J. Braz. Chem. Soc.

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The accumulation of antibiotics in wastewater has led to the development and spreading of antibiotic resistance in the environment. Amoxicillin (Amox), a beta-lactamic antibiotic, is one of the most frequently consumed antibiotics in the world. We have applied two metal-organic frameworks (MOFs) containing zinc(II) as platforms to degrade Amox. We have predicted the adsorption of this antibiotic via molecular docking calculations which have been further corroborated by means of Fourier transform infrared and UV-Vis spectroscopies, thermogravimetric analysis, X-ray diffraction and scanning microscopy measurements. We have subsequently performed mass spectrometry analysis of Amox@zeolitic imidazolate framework-8 (ZIF-8) and Amox@Zn(1,4-benzenedicarboxylate) (ZnBDC) to demonstrate the degradation of Amox upon contact with the Zn-containing frameworks. We propose a possible pathway for the degradation of Amox involving the cleavage of the four-membered β-lactam ring. These Zn-containing frameworks provide a biocompatible platform for the degradation in solution of Amox, which should also be suitable to degrade other β-lactam antibiotics.Keywords: β-lactamase activity, gentamicin, β-lactam catalysis, penicilloic and penilloic acids, biocompatible frameworks IntroductionIn the last decade, antibiotics have emerged as novel environmental pollutants. The widespread use of antibiotics in human and veterinary medicine, animal husbandry, plant production and aquaculture has led to high consumption and the gradual accumulation of antibiotics in the environment (e.g., wastewater, landfills, industrial and hospital effluents). [1][2][3][4][5][6] From 100,000 to 200,000 t of antibiotics are consumed per year in hospitals, homes, veterinary use and aquaculture throughout the world. On average, high-income countries generate ca. 0.5 kg of hazardous waste per bed per day whereas low-income countries generate ca. 0.2 kg. Furthermore, low-income countries do not separate hospital waste into hazardous or non-hazardous wastes, making the real quantity of hazardous waste much higher, as reported by the World Health Organization (WHO).Environmental accumulation of antibiotics has raised serious concerns about the induction of antibiotic resistance. [8][9][10] The exposure of bacteria to the subinhibitory antibiotic concentrations found in many natural environments such as sewage water and sludge, rivers, lakes and even drinking water is a crucial aspect of the current antibiotic resistance crisis.11-14 Furthermore, the incomplete absorption or metabolism of antibiotics in target organisms may lead to excretion rates from 5 to 90% of the dose in the form of metabolites or as parent compounds. 15,16 The chemical structure of antibiotics often contains cyclic moieties such as benzene rings, piperazine units, hexahydropyrimidines, sulfonamides, quinolone, and morpholine groups.5 Upon metabolic processing in humans and animals, these meta-stable compounds yield activated metabolites, which are continuously released in Metal Organic Framewor...

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Cytotoxicity and slow release of the anti-cancer drug doxorubicin from ZIF-8

Cited by 267 publications

References 49 publications

Bio-Inspired Metal-Organic Frameworks in the Pharmaceutical World: A Brief Review

Bio-Inspired Metal-Organic Frameworks in the Pharmaceutical World: A Brief Review

Doxorubicin loaded nanodiamond-silk spheres for fluorescence tracking and controlled drug release

Metal Organic Frameworks for Selective Degradation of Amoxicillin in Biomedical Wastes

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