Cytotoxic T lymphocyte antigen-4 promoter variants in breast cancer

CTLA-4 genotype and relapse incidence in patients with acute myeloid leukemia in first complete remission after induction chemotherapy

“…The G allele of þ 49A/G and the CT60 G allele have been reported to increase susceptibility to several autoimmune diseases 4,5 but it has also been related to a decrease in graft-versus-host disease after allogeneic transplantation. 6 Moreover, certain CTLA-4 polymorphisms have been reported to be more prevalent in patients with renal cancer or sporadic breast cancer, 7 suggesting that increased expression of CTLA-4 would be associated with a decreased ability of the immune system to detect and eliminate tumor-associated antigens. However, little is known about the relationship between the CTLA-4 genotype and the incidence of cancer relapse once complete remission has been obtained through chemotherapy.…”

CTLA-4 Gene +49 A/G Polymorphism in Prostate Cancer Patients in Turkish Population

“…8 These results of their studies confirm the findings of two other studies in Iran 7 and China, 20 which found GG genotype is more frequent in breast cancer patients. Erfani et al 21 genotyped 283 patients and 245 healthy control subjects for 21722 T/C, 21661A/G, and 2318C/T single nucleotide polymorphisms in the promoter region of the CTLA4 gene. Erfani et al 21 found a relationship between AA genotype and lower lymph node involvement and higher ER expression.…”

“…Erfani et al 21 genotyped 283 patients and 245 healthy control subjects for 21722 T/C, 21661A/G, and 2318C/T single nucleotide polymorphisms in the promoter region of the CTLA4 gene. Erfani et al 21 found a relationship between AA genotype and lower lymph node involvement and higher ER expression. However, these researchers indicated that they did not find any difference between their study groups in terms of AG genotype.…”

“…However, these researchers indicated that they did not find any difference between their study groups in terms of AG genotype. Erfani et al 21 identified a relationship between AG genotype and ER expression. Also, Li et al 20 observed a relationship among all CTLA-4 gene polymorphisms with estrogen and progesterone receptors, which was not consistent with our findings.…”

Association between the cytotoxic T-lymphocyte antigen 4-318C/T polymorphism and malignant tumor risk

“…CTLA-4 polymorphisms have been demonstrated to be associated with increased susceptibility to various malignant tumors in a number of different ethnic populations. Previous studies have been performed to determine whether the -318 cytosine/thymine (-318C/T) polymorphism was involved in the etiology of various malignant tumors in Asian population (7)(8)(9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20)(21)(22)(23)(24)(25)(26). However, the results from these studies remain inconclusive and conflicting.…”