Cytotoxic mechanism of Baccharis milleflora (Less.) DC. essential oil

Pereira, Camila Bugnotto; Kanunfre, Carla Cristine; Farago, Paulo Vítor; Borsato, Débora Maria; Budel, Jane Manfron; Maia, Beatriz Helena Lameiro de Noronha Sales; Campesatto, Eliane Aparecida; Sartoratto, Adilson; Miguel, Marílis Dallarmi; Miguel, Obdúlio Gomes

doi:10.1016/j.tiv.2017.04.031

Cited by 21 publications

(19 citation statements)

References 36 publications

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“…Secretory ducts with these characteristics occur in numerous species of Baccharis (Bobek et al, ; Budel et al, ). It has been demonstrated that the volatile oils that are present in the glandular trichomes and secretory ducts have biological activities (Campos et al, 2016; Florão et al, ; Pereira et al, ). According to Pagni and Masini (), in several members of Asteraceae family, the ducts are typically associated to the endodermis, are next to the phloem, and the secretory structures are related with the conducting system.…”

Section: Resultsmentioning

confidence: 99%

“…In Brazil, the genus is represented by about 180 species (Heiden, ). Several biological activities have been reported for various species of Baccharis such as antimicrobial, antibacterial, antifungal, antiprotozoal, antiviral, antioxidant, gastroprotective, antidiabetic, anti‐inflammatory, immunomodulatory, antimutagenic, chemopreventive (Campos et al, 2016), and cytotoxic properties (Pereira et al, ).…”

Section: Introductionmentioning

confidence: 99%

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Foliar anatomy and microscopy of six Brazilian species of Baccharis (Asteraceae)

Budel¹,

Raman

Monteiro³

et al. 2018

Microscopy Res & Technique

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We report for the first time the presence of cluster crystals of calcium oxalate within the glandular trichomes and oil bodies in the mesophyll for Baccharis species. Moreover, the comparative leaf anatomy and micro-morphology of six species of Baccharis, namely B. illinita, B. microdonta, B. pauciflosculosa, B. punctulata, B. reticularioides, and B. sphenophylla is investigated by light and scanning electron microscopy. The studied species exhibited differences in their leaf anatomical features such as the morphology of the cuticle, type and occurrence of the stomata, presence or absence of glandular trichomes, shape of the flagelliform trichomes, and the arrangement of the mesophyll tissues. These differences can be helpful in the species identification and classification and could represent informative characters for the reconstruction of the evolution of the genus.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Foliar anatomy and microscopy of six Brazilian species of Baccharis (Asteraceae)

Budel¹,

Raman

Monteiro³

et al. 2018

Microscopy Res & Technique

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“…Glandular trichomes represent one of the types of secretory structures of aromatic plants and produce and accumulate secondary metabolites with biological activities as seen in several families such as Asteraceae (Budel et al, a, b; Pereira et al, ), Lamiaceae (Conti et al, ; Justus et al, ), and Verbenaceae (Passos et al, ). The micromorphology, number, and distribution of glandular trichomes can be useful as distinguishing features at the subfamily level of Lamiaceae (Ascensão, Marques, & Pais, ).…”

Section: Resultsmentioning

confidence: 99%

Anatomy, micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

Almeida

Raman

Raeski

et al. 2020

Microscopy Res & Technique

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This article enumerates the detailed anatomy of Cantinoa althaeifolia (Lamiaceae) illustrated with light and scanning electron microscopy images. The anatomical markers include the presence of branched nonglandular trichomes and capitate, peltate, and clavate types of glandular trichomes; prismatic crystals on the leaf and stem surfaces; and oil droplets in the leaf mesophyll. Histochemical tests and EDS analyses were performed in order to detect the composition of certain cells and their contents. The key findings of the present study can contribute to the taxonomy, species identification, and quality control of Cantinoa althaeifolia. K E Y W O R D S crystals, leaf anatomy, micromorphology, stem anatomy, trichomes

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“…Monoterpenoids and sesquiterpenoids are frequently found in the EOs of Baccharis [ 3 , 30 ]. Sesquiterpenoids seemed to be more abundant in the majority of the species [ 3 , 6 , 7 , 16 , 22 , 30 , 31 , 32 , 33 ]. However, the EO of some species contained more monoterpenoids than sesquiterpenoids, such as in B. obovata [ 21 ], B. schultzii , B. regnelli Sch.…”

Section: Resultsmentioning

confidence: 99%

“…Many of the medicinal properties described for Baccharis are attributed to their EOs [ 3 ]. The EOs of the genus have been reported to have several biological activities, including antibacterial, antifungal [ 9 , 10 ], antiprotozoal, antiviral, antioxidant, anti-inflammatory, antimutagenic, antiulcer, chemopreventive, repellent, sedative [ 7 , 11 , 12 , 13 ], schistosomicidal [ 14 ], and larvicidal against Aedes aegypti [ 15 ] and cytotoxic properties [ 16 ]. B. microdonta DC.…”

Section: Introductionmentioning

confidence: 99%

Essential Oils of Five Baccharis Species: Investigations on the Chemical Composition and Biological Activities

et al. 2018

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This paper provides a comparative account of the essential oil chemical composition and biological activities of five Brazilian species of Baccharis (Asteraceae), namely B. microdonta, B. pauciflosculosa, B. punctulata, B. reticularioides, and B. sphenophylla. The chemical compositions of three species (B. pauciflosculosa, B. reticularioides, and B. sphenophylla) are reported for the first time. Analyses by GC/MS showed notable differences in the essential oil compositions of the five species. α-Pinene was observed in the highest concentration (24.50%) in B. reticularioides. Other major compounds included α-bisabolol (23.63%) in B. punctulata, spathulenol (24.74%) and kongol (22.22%) in B. microdonta, β-pinene (18.33%) and limonene (18.77%) in B. pauciflosculosa, and β-pinene (15.24%), limonene (14.33%), and spathulenol (13.15%) in B. sphenophylla. In vitro analyses for antimalarial, antitrypanosomal, and insecticidal activities were conducted for all of the species. B. microdonta and B. reticularioides showed good antitrypanosomal activities; B. sphenophylla showed insecticidal activities in fumigation bioassay against bed bugs; and B. pauciflosculosa, B. reticularioides, and B. sphenophylla exhibited moderate antimalarial activities. B. microdonta and B. punctulata showed cytotoxicity. The leaves and stems of all five species showed glandular trichomes and ducts as secretory structures. DNA barcoding successfully determined the main DNA sequences of the investigated species and enabled authenticating them.

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Cytotoxic mechanism of Baccharis milleflora (Less.) DC. essential oil

Cited by 21 publications

References 36 publications

Foliar anatomy and microscopy of six Brazilian species of Baccharis (Asteraceae)

Foliar anatomy and microscopy of six Brazilian species of Baccharis (Asteraceae)

Anatomy, micromorphology, and histochemistry of leaves and stems of Cantinoa althaeifolia (Lamiaceae)

Essential Oils of Five Baccharis Species: Investigations on the Chemical Composition and Biological Activities

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