Cytotoxic effects of mono- and di-rhamnolipids from Pseudomonas aeruginosa MR01 on MCF-7 human breast cancer cells

Rahimi, Kobra; Lotfabad, Tayebe Bagheri; Jabeen, Farhat; Ganji, Shahla Mohammad

doi:10.1016/j.colsurfb.2019.06.058

Cited by 47 publications

(42 citation statements)

References 44 publications

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“…The mechanism of inhibition appeared to be the induction of apoptosis. Rahimi et al [ 174 ] confirmed the anti-cancer properties of R1 and R2 (on the MCF7 human breast cancer cells) and the lower IC 50 of R1 (25.87 µg/mL) compared to R2 (31.00 µg/mL). Others have also confirmed the anticancer potential of rhamnolipids [ 175 ].…”

Section: Anti-cancer Propertiesmentioning

confidence: 92%

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

et al. 2020

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Surface active agents (SAAs) are molecules with the capacity to adsorb to solid surfaces and/or fluid interfaces, a property that allows them to act as multifunctional ingredients (e.g., wetting and dispersion agents, emulsifiers, foaming and anti-foaming agents, lubricants, etc.) in a widerange of the consumer products of various industrial sectors (e.g., pharmaceuticals, cosmetics, personal care, detergents, food, etc.). Given their widespread utilization, there is a continuously growing interest to explore their role in consumer products (relevant to promoting human health) and how such information can be utilized in order to synthesize better chemical derivatives. In this review article, weaimed to provide updated information on synthetic and biological (biosurfactants) SAAs and their health-promoting properties (e.g., anti-microbial, anti-oxidant, anti-viral, anti-inflammatory, anti-cancer and anti-aging) in an attempt to better define some of the underlying mechanism(s) by which they exert such properties.

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Section: Anti-cancer Propertiesmentioning

confidence: 92%

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

et al. 2020

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“…Rahimi et al, in their study, isolated RL1 and RL2 from MR01 strain of PA and tested their cytotoxicity against MCF-7 cells [ 49 ]. They found that although both RLs inhibited the proliferation of MCF-7 cells but RL1 was more effective in killing the cancer cells [ 49 ]. They found that the pronounced effect on the cell viability was through their interaction with cell membrane.…”

Section: Applications Of Gycolipids Biosurfactant: Rhamnolipidsmentioning

confidence: 99%

“…They found that the pronounced effect on the cell viability was through their interaction with cell membrane. Results of phase-contrast microscopy revealed the changes in the morphology of MCF-7 cells after their treatment with mono- and di-rhamnolipids at 25, 50, 100 µg/mL concentrations for 48 h [ 49 , 50 ]. Rhamnolipids treated MCF-7 cells have round and shrunken shapes whereas control MCF-7 cells have polygonal and cuboidal shapes as shown in Fig.…”

Section: Applications Of Gycolipids Biosurfactant: Rhamnolipidsmentioning

confidence: 99%

“…Rhamnolipids treated MCF-7 cells have round and shrunken shapes whereas control MCF-7 cells have polygonal and cuboidal shapes as shown in Fig. 3 a, b [ 49 , 50 ]. Rhamnolipids treated MCF-7 cells lost their contact with adjacent cells resulted in their detachment from the surfaces leading to their flotation [ 49 ].…”

Section: Applications Of Gycolipids Biosurfactant: Rhamnolipidsmentioning

confidence: 99%

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Rhamnolipid the Glycolipid Biosurfactant: Emerging trends and promising strategies in the field of biotechnology and biomedicine

et al. 2021

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Rhamnolipids (RLs) are surface-active compounds and belong to the class of glycolipid biosurfactants, mainly produced from Pseudomonas aeruginosa. Due to their non-toxicity, high biodegradability, low surface tension and minimum inhibitory concentration values, they have gained attention in various sectors like food, healthcare, pharmaceutical and petrochemicals. The ecofriendly biological properties of rhamnolipids make them potent materials to be used in therapeutic applications. RLs are also known to induce apoptosis and thus, able to inhibit proliferation of cancer cells. RLs can also act as immunomodulators to regulate the humoral and cellular immune systems. Regarding their antimicrobial property, they lower the surface hydrophobicity, destruct the cytoplasmic membrane and lower the critical micelle concentration to kill the bacterial cells either alone or in combination with nisin possibly due to their role in modulating outer membrane protein. RLs are also involved in the synthesis of nanoparticles for in vivo drug delivery. In relation to economic benefits, the post-harvest decay of food can be decreased by RLs because they prevent the mycelium growth, spore germination of fungi and inhibit the emergence of biofilm formation on food. The present review focuses on the potential uses of RLs in cosmetic, pharmaceutical, food and health-care industries as the potent therapeutic agents.

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“…Therefore, these areas should be closely examined and evaluated [ 74 ]. Additionally, biosurfactants produced by microorganisms are generally produced as a mixture of congeners rather than a single compound, and since different congeners have been shown to have different bioactivities, pure preparation of individual congeners needs to be investigated to accurately determine the efficacy of biosurfactants and their appropriate concentrations for use [ 154 ].…”

Section: Challenges and Solutions For Biosurfactant Applicationsmentioning

confidence: 99%

Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations

et al. 2020

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Cosmetic and personal care products are globally used and often applied directly on the human skin. According to a recent survey in Europe, the market value of cosmetic and personal care products in Western Europe reached about 84 billion euros in 2018 and are predicted to increase by approximately 6% by the end of 2020. With these significant sums of money spent annually on cosmetic and personal care products, along with chemical surfactants being the main ingredient in a number of their formulations, of which many have been reported to have the potential to cause detrimental effects such as allergic reactions and skin irritations to the human skin; hence, the need for the replacement of chemical surfactants with other compounds that would have less or no negative effects on skin health. Biosurfactants (surfactants of biological origin) have exhibited great potential such as lower toxicity, skin compatibility, protection and surface moisturizing effects which are key components for an effective skincare routine. This review discusses the antimicrobial, skin surface moisturizing and low toxicity properties of glycolipid and lipopeptide biosurfactants which could make them suitable substitutes for chemical surfactants in current cosmetic and personal skincare pharmaceutical formulations. Finally, we discuss some challenges and possible solutions for biosurfactant applications.

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Cytotoxic effects of mono- and di-rhamnolipids from Pseudomonas aeruginosa MR01 on MCF-7 human breast cancer cells

Cited by 47 publications

References 44 publications

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

Surface Active Agents and Their Health-Promoting Properties: Molecules of Multifunctional Significance

Rhamnolipid the Glycolipid Biosurfactant: Emerging trends and promising strategies in the field of biotechnology and biomedicine

Microbial Biosurfactants in Cosmetic and Personal Skincare Pharmaceutical Formulations

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