2012
DOI: 10.1016/j.toxicon.2012.03.002
|View full text |Cite
|
Sign up to set email alerts
|

Abstract: Neoplastic transformation is the abnormal proliferation of cells. These transformations are often related to changes in cell surface glycoconjugates which can be detected by lectins. We evaluated the anti-tumor potential of BlL, a galactoside-binding lectin isolated from Bothrops leucurus venom as well as its cytotoxicity and hemolysis activity. The phosphatidylserine externalization and mitochondrial membrane potential were also determined. BlL exhibited cytotoxic activity against all tumor cell lines tested … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
3
1
1

Citation Types

0
23
0
7

Year Published

2015
2015
2022
2022

Publication Types

Select...
4
2
1

Relationship

0
7

Authors

Journals

citations
Cited by 48 publications
(30 citation statements)
references
References 38 publications
0
23
0
7
Order By: Relevance
“…Number of described snake venom proteins, including metalloproteinase, disintegrin, CLP, PLA 2 and LAAO, purified from the venom of different species have been shown to induce apoptosis interacting different pathways. 12,[17][18][19][20][21][22]40 In the present study, preliminary information showing the induction of apoptosis in K562 cells after exposure to M. lebetina obtusa venom was obtained by the observation of the morphological characteristics of apoptosis as well as activation of caspase-3 by immunohistochemistry. Caspase-3 is one of the key executioners of apoptosis.…”
Section: 3639mentioning
confidence: 99%
See 2 more Smart Citations
“…Number of described snake venom proteins, including metalloproteinase, disintegrin, CLP, PLA 2 and LAAO, purified from the venom of different species have been shown to induce apoptosis interacting different pathways. 12,[17][18][19][20][21][22]40 In the present study, preliminary information showing the induction of apoptosis in K562 cells after exposure to M. lebetina obtusa venom was obtained by the observation of the morphological characteristics of apoptosis as well as activation of caspase-3 by immunohistochemistry. Caspase-3 is one of the key executioners of apoptosis.…”
Section: 3639mentioning
confidence: 99%
“…32,33 There are limited studies investigating the induction of apoptosis in K562 cells, after treatment with crude snake venom or purified proteins. 14,17,19,22,38,[41][42][43] Samel et al 19 investigated the effect of Sephadex G-100 chromatography fractions of M. lebetina turanica (subspecies was not mentioned in the paper but assigned according to the locality) venom and also purified HUVEC apoptosis inducing metalloproteinase (VLAIP). The first fraction reported to inhibit the viability of K562 cells about 30%.…”
Section: 3639mentioning
confidence: 99%
See 1 more Smart Citation
“…Além disso, algumas peçonhas apresentam atividade hemolítica e/ou citotóxica, induzindo morte, geralmente por apoptose, em células humanas (BERNHEIMER et al, 1980;NUNES et al, 2012).…”
Section: I) Organismos Não Formicidaeunclassified
“…Muitas dessas espécies também trazem prejuízos à agricultura (DIEHL-FLEIG, 2006), além de serem vetores de patógenos aos humanos (ZARZUELA et al, 2002;PESQUERO et al, 2008;GARCIA et al, 2011;AQUINO et al, 2012;AQUINO et al, 2012). Iop et al, 2009;Munhae et al, 2009;Souza et al, 2012;Lutinski et al, 2013;Melo et al, 2014 Gnamptogenys sulcata (Smith, Neoponera verenae (Forel, 1922) Bahia (2 cidades Morini et al, 2007;Munhae et al, 2009;Souza et al, 2012;Lutinski et al, 2013Odontomachus haematodus (Linnaeus, 1758 Bahia (3 cidades) Mata Atlântica…”
Section: Poneromorfas Sinantrópicasunclassified