Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1

Li, Xiang; Tian, Ye; Shen, Yang; Zhang, Yamei; Qin, Jianchun

doi:10.1016/j.bmcl.2013.03.044

Cited by 50 publications

(26 citation statements)

References 8 publications

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“…Chaetoglobin B was a dimer with an unprecedented skeleton characterized by NMR spectrum and X‐ray analysis . The structure of chaetomugilide A was elucidated in our previous research, and it showed significant cytotoxicity against HepG‐2 cells with an IC 50 value of 1.7 μ m …”

Section: Resultsmentioning

confidence: 99%

“…[19] The structure of chaetomugilide A was elucidated in our previous research, and it showed significant cytotoxicity against HepG-2 cells with an IC 50 value of 1.7 μM. [20] Compound 1 was assessed for its cytotoxic activity to HepG-2 tumor cell lines and the growth inhibitory activity of brine shrimp (A. salina). Compound 1 showed moderate cytotoxicity against HepG-2 cells with an IC 50 value of 38.6 μM, and significant toxicity toward brine shrimp at a concentration of 10 μg/ml, with a mortality rate of 68.6 %.…”

Section: Resultsmentioning

confidence: 99%

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Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum

Song

Ding

et al. 2020

Chemistry & Biodiversity

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A new azaphilone, chaephilone E, eight azaphilone derivatives, and three chaetoglobosins were isolated from endophytic fungi Chaetomium globosum. The structures of the compounds were elucidated by 1D and 2D NMR as well as HR‐ESI‐MS data, and the absolute configuration of chaephilone E was established on the basis of electronic circular dichroism and NOESY spectrum. The activity of chaephilone E was evaluated via the cytotoxic assay (human hepatoma cell lines HepG‐2) and brine shrimp (Artemia salina) bioassay.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum

Song

Ding

et al. 2020

Chemistry & Biodiversity

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“…[25] Few plant pigments such as azaphilone alkaloids, namely, chaetomugilides A-C isolated from Chaetomium globosum TY1, an endophytic fungus found in Ginkgo biloba showed cytotoxic activities against human cancer cell line HePG2. [26] Similarly, apigenin, naringenin flavonoids from Sorghum bicolor, [27] phenolics from berry fruits Vitis vinifera, [28] (-) epigallocatechin gallate from green tea, [29] and plyphenolic red pigment from Solanum tubersoum showed in vitro inhibition of colon cancer. [30] Carotenoid derivative inhibits nuclear fraction factor kappa B activity in cancer cells.…”

Section: Review Articlementioning

confidence: 99%

Untitled

Upadhyay¹

2018

IJGP

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Present review article explains the dietary use of plant pigments and therapeutic effects against cancer. Important plant pigments such as anthocyanins, lycopene, carotenoids, chlorophyll, and betalains are explained for their anticancer effects. Plant pigments are secondary metabolites which obstruct cancer cell proliferation; stop growth and cell division in cancer cells. These inhibit cellular processes in cancer cells such as signaling pathways, cell cycle, induce apoptosis, and autophagy. Besides, anticancer activity these also assist in controlling high blood pressure, obesity, hyperglycemia, hypercholesterolemia, and restore cardiovascular problems. A full series of pigments is available in various plants families which might show protective effects against cancer. Plant pigments are edible, nutritionally rich and therapeutically suitable. Due to their health-promoting effects there is a growing public interest to consume green vegetables, fruits, sprouted seeds, pigmented cereals, and processed low energy antioxidative functional food. For widening their use, these could be harvested using recombinant gene technology to add to processed foods as a coloring agent. Plant pigments as natural plant products or its by-products are highly useful for the development of a large variety of functional foods, digestive ingredients, additives, as well as cosmetic products. These could be naturally added to genetically suitable modified foods by applying genomic tools. No doubt plant secondary metabolites will also fulfill needs of present-day medicine and show great promise for the future.

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“…Compounds 1-5 were evaluated for their cytotoxic activities to HepG2 tumor cell line and the growth inhibitory activity towards brine shrimp by using the colorimetric assay and small modified microtiter-plate method, respectively as previously described in the literature [18,19].…”

Section: Cytotoxic Evaluationmentioning

confidence: 99%

Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada

et al. 2020

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Three new inositol angelate compounds (1–3) and two new tirucallane-type alkaloids (4 and 5) were isolated from the Amoora dasyclada, and their structures were established mainly by means of combination of 1D and 2D nuclear magnetic resonance and HR-ESI-MS. Based on cytotoxicity testing, compounds 4 and 5 exhibited significant cytotoxic activity against human cancer cell line HepG2 with IC50 value at 8.4 and 13.2 μM. In addition, compounds 4 and 5 also showed remarkable growth inhibitory activity to Artemia salina larvae.

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Cytotoxic azaphilone alkaloids from Chaetomium globosum TY1

Cited by 50 publications

References 8 publications

Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum

Identification of a Unique Azaphilone Produced by Chaetomium globosum Isolated from Polygonatum sibiricum

Untitled

Cytotoxic Activity of Inositol Angelates and Tirucallane-Type Alkaloids from Amoora Dasyclada

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