Biochemical Pharmacology volume 79, issue 1, P21-29 2010 DOI: 10.1016/j.bcp.2009.07.018 View full text
Swathi Damaraju, Vijaya L. Damaraju, Delores Mowles, Michael B. Sawyer, Sambasivarao Damaraju, Carol E. Cass

Abstract: World wide incidence of bladder cancer is rising with nearly 13,760 deaths attributed to bladder cancer in 2007 in the USA. Tumor types of the urothelium include transitional cell carcinomas, squamous cell carcinomas, and adenocarcinomas. This study was undertaken to determine gemcitabine's efficacy against bladder cancer cell lines of different origins (HTB2, a papilloma; HTB3, a squamous cell carcinoma; and HTB4, a transitional cell carcinoma). Roles of nucleoside transporters and key enzymes in gemcitabine …

expand abstract