Multiple inositol polyphosphate phosphatase (MIPP) is an enzyme that, in vitro, has the interesting property of degrading higher inositol polyphosphates to the Ca 2؉ second messenger, inositol 1,4,5-trisphosphate (Ins(1,4,5)P 3 ), independently of inositol lipid breakdown. We hypothesized that a truncated cytosolic form of the largely endoplasmic reticulum-confined MIPP (cyt-MIPP) could representanimportantnewtoolintheinvestigationofIns(1,4,5)P 3 -dependent intracellular Ca 2؉ homeostasis. ] i , the latter be…
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