Cytosolic long-chain acyl-CoA hydrolase, a suitable parameter to measure hepatic response to peroxisome proliferators

Peroxisome Proliferators Differentially Regulate Long‐chain Acyl‐CoA Thioesterases in Rat Liver

“…This dimer could be involved in heterodimerisation of the nuclear hormone receptors, PP-activated receptor and retinoid X receptor, that interact with enhancer-like PP-responsive elements [40,41] which are located upstream of the genes encoding some of the induced enzymes [32,[42][43][44]. It has recently been suggested that induction of cytosolic acyl-CoA thioesterase activity is a good marker for peroxisome proliferation [45]. If the ligand for PP-activated receptor is a fatty acid, its acyl-CoA analog, or a subsequent metabolite [46], the induced cytosolic thioesterases could be involved in the proliferative response by modulating of the availability of the free fatty acidacyl-CoA.…”

Peroxisome Proliferators Differentially Regulate Long‐chain Acyl‐CoA Thioesterases in Rat Liver

“…This dimer could be involved in heterodimerisation of the nuclear hormone receptors, PP-activated receptor and retinoid X receptor, that interact with enhancer-like PP-responsive elements [40,41] which are located upstream of the genes encoding some of the induced enzymes [32,[42][43][44]. It has recently been suggested that induction of cytosolic acyl-CoA thioesterase activity is a good marker for peroxisome proliferation [45]. If the ligand for PP-activated receptor is a fatty acid, its acyl-CoA analog, or a subsequent metabolite [46], the induced cytosolic thioesterases could be involved in the proliferative response by modulating of the availability of the free fatty acidacyl-CoA.…”

Peroxisome Proliferators Differentially Regulate Long‐chain Acyl‐CoA Thioesterases in Rat Liver

“…This dimer could be involved in heterodimerisation of the nuclear hormone receptors, PP-activated receptor and retinoid X receptor, that interact with enhancer-like PP-responsive elements [40,41] which are located upstream of the genes encoding some of the induced enzymes [32,[42][43][44]. It has recently been suggested that induction of cytosolic acyl-CoA thioesterase activity is a good marker for peroxisome proliferation [45]. If the ligand for PP-activated receptor is a fatty acid, its acyl-CoA analog, or a subsequent metabolite [46], the induced cytosolic thioesterases could be involved in the proliferative response by modulating of the availability of the free fatty acidacyl-CoA.…”

Peroxisome Proliferators Differentially Regulate Long‐chain Acyl‐CoA Thioesterases in Rat Liver

“…This dimer could be involved in heterodimerisation of the nuclear hormone receptors, PP-activated receptor and retinoid X receptor, that interact with enhancer-like PP-responsive elements [40,41] which are located upstream of the genes encoding some of the induced enzymes [32,[42][43][44]. It has recently been suggested that induction of cytosolic acyl-CoA thioesterase activity is a good marker for peroxisome proliferation [45]. If the ligand for PP-activated receptor is a fatty acid, its acyl-CoA analog, or a subsequent metabolite [46], the induced cytosolic thioesterases could be involved in the proliferative response by modulating of the availability of the free fatty acidacyl-CoA.…”