Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models

Sales, Igor Rafael Praxedes de; Formiga, Rodrigo de Oliveira; Machado, Flávia Danniele Frota; Nascimento, Raphaela Francelino do; Pessoa, Matheus Marley Bezerra; Barros, Monique Emanuela Frutuoso Xavier; Vieira, Giciane Carvalho; Gadelha, Francisco Allysson Assis Ferreira; Marinho, Alexsandro Fernandes; Barbosa-Filho, José Maria; Júnior, Raimundo Fernandes de Araújo; Antunes, Aurigena Araújo; Batista, Leônia Maria

doi:10.1016/j.jep.2018.04.019

Cited by 19 publications

(16 citation statements)

References 79 publications

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“…Pyloric-ligation induced gastric-ulceration resulted from auto-digestion and break down of the stomach wall [78] by the digestive effect of accumulated gastric juice (gastric acid and pepsin), interference of gastric blood circulation [33,79], and increased production of free radicals [12]. Drugs which express a reduction in gastric juice secretion and elevation in mucus production can prevent the pyloric-ligation induced gastric-ulcerations [80].…”

Section: Discussionmentioning

confidence: 99%

“…Since long ago, natural products from traditional medicine have represented an inspiration for the development of new drugs [12]. The use of herbal drugs for the treatment of gastrointestinal disorders, as a part of complementary and alternative medicine (CAM), is increasing in developed and developing countries.…”

Section: Introductionmentioning

confidence: 99%

“…Medicinal/herbal plants and extracts represent some of the most attractive resources of new drugs and have shown promising results for the treatment of gastric ulcers [17,18,19,20,21,22,23,24]. The natural products obtained from medicinal plants, including flavonoids, polyphenols, terpenoids [18], saponins [24], alkaloids [12], and mucilaginous polysaccharides [25], show immense pharmacological significance such as anti-inflammatory, antimicrobial, antiulcer, anti-oxidant, and anticancer activities [24,26,27]. In in vivo experiments on animal models showed that many plants and their extracts have considerable anti-ulcerogenic properties [16] through anti-oxidant, muco-protective, and gastric anti-secretory activity in comparison with that of reference drugs [28].…”

Section: Introductionmentioning

confidence: 99%

“…Alkaloids have a gastro-protective activity, which may involve the participation of sulfhydryl compounds, NO and PG, as well as reduction of IL-1β and TNF-α contents and elevation of GSH contents [12]. Most of the reported alkaloids possess prophylactic anti-ulcerogenic activity through enhancing mucus production in addition to the anti-oxidant activity [24].…”

Section: Introductionmentioning

confidence: 99%

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Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

et al. 2019

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Recently, an alternative disease treatment approach is the research of medicaments from traditional medicine. Plants with anti-oxidant capabilities are used as herbal treatments for ulcer diseases. Medicinal/herbal extracts containing phytoconstituents have significant anti-ulcer activities in in vivo experiments on animal models, compared to reference drugs. The current study aims to inspect gastro-protective as well as in vitro and in vivo anti-oxidant potential of Althaea officinalis and Solanum nigrum extracts on pyloric-ligation/indomethacin-induced gastric-ulceration in rats. Rats were divided into six groups: normal control, gastric ulcer control, two standard pretreatment groups receiving omeprazole and misoprostol, and two test pretreatment groups receiving Althaea officinalis and Solanum nigrum. Pretreatments were administrated orally for 14 days. On the 15th day, animals, excluding the normal control group, were exposed to pyloric-ligation followed by indomethacin injection. After four hours, the rat’s stomachs were removed and gastric juice and blood samples were collected. Pyloric-ligation/indomethacin administration caused considerable elevation in ulcer number, ulcer index, acid and pepsin productivity, aggressive factors, and gastric mucosal lipid-peroxide contents. Moreover, reduction in titratable acidity, gastric mucosal nitric-oxide, anti-oxidant contents, and protective factors accompanied gastric-ulceration. Additionally, elevation in pro-inflammatory cytokines content and reduction in cystathionine-β-synthase and heme-oxygenase-1 expression was witnessed. Omeprazole, misoprostol, Althaea officinalis, and Solanum nigrum pretreatments fixed blood and tissue biomarkers, thereby protecting them from pyloric-ligation/indomethacin-induced gastric-ulceration in rats, which is hopeful for clinical examinations.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

et al. 2019

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“…These antibodies were immunomodulatory, since they respond in a camcorder manner. IgE molecules in an ovalbumin‐induced allergy model increased cell levels in a food allergy model and decreased cell proliferation and immunoglobulin production …”

Section: Introductionmentioning

confidence: 99%

Antibiotic‐Potentiating Activity of Phanostenine Isolated from Cissampelos sympodialisEichler

Cunha

Camilo

Nonato

et al. 2019

Chemistry & Biodiversity

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Cissampelos sympodialis EICHLER is well studied and investigated for its antiasthmatic properties, but there are no data in the literature describing antibacterial properties of alkaloids isolated from this botanical species. This work reports the isolation and characterization of phanostenine obtained from roots of C. sympodialis and describes for the first time its antimicrobial and antibiotic modulatory properties. Phanostenine was first isolated from Cissampelos sympodialis and its antibacterial activities were determined. Chemical structures of the alkaloid isolate were determined using spectroscopic and chemical analyses. Phanostenine was also tested for its antibacterial activity against standard strains and clinical isolates of Escherichia coli and Staphylococcus aureus. Minimal inhibitory concentration (MIC) was determined in a microdilution assay and for the evaluation of antibiotic resistance-modifying activity. MIC of the antibiotics was determined in the presence or absence of phanostenine at sub-inhibitory concentrations. The evaluation of antibacterial activity by microdilution assay showed activity for all strains with better values against S. aureus ATCC 12692 and E. coli 27 (787.69 mM). The evaluation of aminoglycoside antibiotic resistance-modifying activity showed reduction in the MIC of the aminoglycosides (amikacin, gentamicin and neomycin) when associated with phanostenine, MIC reduction of antibiotics ranging from 21 % to 80 %. The data demonstrated that phanostenine possesses a relevant ability to modify the antibiotic activity in vitro. We can suggest that phanostenine presents itself as a promising tool as an adjuvant for novel antibiotics formulations against bacterial resistance.

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Anti-inflammatory Activity of Medicinal Plants: Present Status and Future Perspectives

Chouhan

Guleria

2020

Botanical Leads for Drug Discovery

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Cytoprotective, antioxidant and anti-inflammatory mechanism related to antiulcer activity of Cissampelos sympodialis Eichl. in animal models

Cited by 19 publications

References 79 publications

Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

Gastro-Protective and Anti-Oxidant Potential of Althaea officinalis and Solanum nigrum on Pyloric Ligation/Indomethacin-Induced Ulceration in Rats

Antibiotic‐Potentiating Activity of Phanostenine Isolated from Cissampelos sympodialisEichler

Anti-inflammatory Activity of Medicinal Plants: Present Status and Future Perspectives

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