Cytophotometric DNA analysis of esophageal dysplasia and carcinoma induced in rats by N-methyl-N-amylnitrosamine

Evolution of DNA ploidy during squamous cell carcinogenesis in the esophagus

“…This trend was especially observed for synchronous and metachronous lesions. Similar results were observed in various early esophageal lesions induced in rats 16 …”

Evolution of DNA ploidy during squamous cell carcinogenesis in the esophagus

“…This trend was especially observed for synchronous and metachronous lesions. Similar results were observed in various early esophageal lesions induced in rats 16 …”

Histological and biological characteristics of esophageal dysplasia

“…Multiplicity of squamous cell carcinoma and intraepithelial spread of main lesions were also frequently observed [7,8]. We performed a cytophotometric DNA analysis on chemically induced esophageal carcinoma in rats [9] and used immunohistochemical detection of proliferating cell nuclear antigen (PCNA) for resected human esophageal specimens [10]. Results indicated that the biological nature of the dysplasia was similar to a cancer lesion.…”

Evolution of DNA ploidy during squamous cell carcinogenesis in the esophagus

“…This trend was especially observed for synchronous and metachronous lesions. Similar results were observed in various early esophageal lesions induced in rats 16 …”

Histological and biological characteristics of esophageal dysplasia

“…Multiplicity of squamous cell carcinoma and intraepithelial spread of main lesions were also frequently observed [7,8]. We performed a cytophotometric DNA analysis on chemically induced esophageal carcinoma in rats [9] and used immunohistochemical detection of proliferating cell nuclear antigen (PCNA) for resected human esophageal specimens [10]. Results indicated that the biological nature of the dysplasia was similar to a cancer lesion.…”

Evolution of DNA ploidy during squamous cell carcinogenesis in the esophagus

“…This trend was especially observed for synchronous and metachronous lesions. Similar results were observed in various early esophageal lesions induced in rats 16 …”

Histological and biological characteristics of esophageal dysplasia

“…Multiplicity of squamous cell carcinoma and intraepithelial spread of main lesions were also frequently observed [7,8]. We performed a cytophotometric DNA analysis on chemically induced esophageal carcinoma in rats [9] and used immunohistochemical detection of proliferating cell nuclear antigen (PCNA) for resected human esophageal specimens [10]. Results indicated that the biological nature of the dysplasia was similar to a cancer lesion.…”