Cytomorphology of sebaceous carcinoma with analysis of p40 antibody expression

Jain, Deepali; Mathur, Sandeep; Sharma, Mehar Chand; Iyer, Venkateswaran K.

doi:10.1002/dc.23250

Cited by 14 publications

(13 citation statements)

References 18 publications

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“…4 the positivity of p40 in 20 previously diagnosed cases of sebaceous carcinoma; however, positivity for p40 does not indicate that a tumor is malignant, as p40 is also expressed in the basal or germinative layer of sebaceous epithelium. 5 We suspect that the adipophilin negative, p40 positive cells in our case represent an immature basaloid or germinative component, consistent with that seen in more typical sebaceous epitheliomas, rather than a malignant component. Our case also showed CK5/6 positivity, which may explain the unique appearance of trabeculae formation, since it is expressed in basaloid cells.…”

Section: Discussionsupporting

confidence: 78%

Benign Sebaceous Epithelioma with Carcinoid-like Trabecular Cell Arrangement

et al. 2018

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A case of 75-year-old woman with sebaceous epithelioma was reported. The histological features were distinct in that it had a sinusoidal and carcinoid-like growth pattern, which has been reported in its malignant counterpart. Immunostaining for adipophilin was positive in the area with lipid-laden vacuolated cells, but the rest of tumor, which had cord-like nests, was negative. MIB index was 2%. CK5/6 and p40 were positive in the cord-like nesting areas. CK7, CK20, alpha SMA, and epithelial membrane antigen were negative in both the cord-like nesting areas and the adipose-like areas. The tumor was diagnosed as sebaceous epithelioma with a trabecular pattern. Dermatopathologists should be aware of this atypical histological pattern of benign sebaceous epithelioma.

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Section: Discussionsupporting

confidence: 78%

Benign Sebaceous Epithelioma with Carcinoid-like Trabecular Cell Arrangement

et al. 2018

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“…Interestingly, recent studies have shown P40 immunostaining in benign and malignant neoplasms other than SqCC. A recent study has demonstrated the role of P40 as a marker for sebaceous lineage, noting that this antibody can be utilized for diagnosing sebaceous carcinoma in the setting of poorly differentiated carcinoma [30]. P40 is also expressed in the cuboidal tumor cells of sclerosing hemangioma of the lung, but not in the polygonal tumor cells [31,34,35].…”

Section: Discussionmentioning

confidence: 99%

Expression of P40 and P63 in lung cancers using fine needle aspiration cases. Understanding clinical pitfalls and limitations

Lilo

Allison

Wang

et al. 2016

Journal of the American Society of Cytopathology

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Background Fine-needle aspiration (FNA) biopsy of lung lesions is a highly accurate method for diagnosing and staging of lung cancers, particularly in patients with advanced cancer. Although, the majority of FNA cases of non-small cell lung carcinoma (NSCLC) can be subclassified by hematoxylin and eosin (H&E) sections, immunohistochemical (IHC) markers are usually necessary for difficult cases. Our previous study has shown that both P40 and P63 demonstrate differential sensitivity and specificity in the subclassification of squamous cell carcinoma (SqCC) using tumor tissue microarrays (TMA). In the present study, we further evaluated the utility of P40 and P63 and the potential pitfalls and limitations associated with the usefulness of these stains in FNA cases. Methods By a computer search of pathology archives, 144 FNA biopsies with diagnoses of lung cancers and P40/P63 stains were identified, including 50 adenocarcinomas (ADCs), 56 SqCCs, 8 small cell lung carcinomas (SCLCs), and 12 cases of poorly differentiated carcinoma (PD CA). Ten benign FNA lung lesions and 8 other malignant neoplasms were also included as controls. Nuclear staining patterns of P40 and P63 were scored semi-quantitatively as 0 (negative), 1 (<10%, weak and focal), or 2 (>10%, strong and diffuse). Results In lung SqCCs, P40 and P63 were positive in 77.3% and 89.5% cases, respectively. In ADCs, P40 was weakly and focally positive in 6.1% cases, and P63 was variably positive in 62.8% cases. In SCLCs, P40 and P63 were focally positive in 12.5% and 50% cases. In PD CAs, no P40 or P63 immunoreactivity was detected. In the group of other neoplasms (n=8) both P40 and P63 were positive in the case of metastatic non-seminomatous germ cell tumor (NSGCT) (n=1), and P63 was positive in the case of metastatic Merkel cell carcinoma (n=1). The sensitivity and specificity of P40 and P63 were 76.9%/93.3%, and 90.2%/50.7% in the lung SqCC. Conclusions P63 has a better sensitivity, and P40 has a better specificity for SqCC. A positive staining pattern with both markers was also found in certain non-SqCC cases. Recognizing limitations of these markers are particularly important in FNA cases.

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“…The role of SOX10 in sebaceous lesions has not been previously investigated; however, negative staining for DOG1 and positive staining for p63, androgen receptor, adipophilin and p40 in these lesions could help differentiate them from AciCC, which shows the opposite immunoprofile [13,17,18,19]. …”

Section: Discussionmentioning

confidence: 99%

Expression of SOX10 in Salivary Gland Oncocytic Neoplasms: A Review and a Comparative Analysis with Other Immunohistochemical Markers

Schmitt

Cohen

Siddiqui³

2015

Acta Cytologica

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Objectives: We evaluated SOX10 (SRY-related HMG-box 10) in differentiating acinic cell carcinoma (AciCC) from other salivary gland neoplasms with oncocytic features on fine-needle aspiration cell blocks (FNA CB) and compared its performance to DOG1 (discovered on gastrointestinal stromal tumor 1). Material and Methods: 35 FNA CB of oncocytic salivary gland neoplasms, i.e. 13 cases of AciCC, 16 of Warthin tumor (WT), 3 of mucoepidermoid carcinoma (MEC) and 3 of oncocytoma (ONC), and 75 salivary gland resections, i.e. 26 AciCC, 7 WT, 36 MEC, 3 ONC, 2 mammary analog secretory carcinomas (MASC) and 1 papillary cystadenoma were stained for SOX10 and DOG1. Results: None of the benign oncocytic neoplasms were immunoreactive for SOX10 on CB or resection, similar to DOG1. On CB, 61.5 and 77% of AciCC were positive for SOX10 and DOG1, respectively. All surgically resected AciCC cases were positive for SOX10 and DOG1; other malignant oncocytic lesions such as MEC and MASC demonstrated variable SOX10 and DOG1 staining. Conclusion: The use of SOX10 may increase the diagnostic accuracy of oncocytic lesions on FNA. In this context, SOX10 is equivalent to DOG1 in ruling out benign lesions such as WT and ONC; however, negative results for SOX10 as well as DOG1 do not favor a benign diagnosis since MEC is often negative for both markers.

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Cytomorphology of sebaceous carcinoma with analysis of p40 antibody expression

Cited by 14 publications

References 18 publications

Benign Sebaceous Epithelioma with Carcinoid-like Trabecular Cell Arrangement

Benign Sebaceous Epithelioma with Carcinoid-like Trabecular Cell Arrangement

Expression of P40 and P63 in lung cancers using fine needle aspiration cases. Understanding clinical pitfalls and limitations

Expression of SOX10 in Salivary Gland Oncocytic Neoplasms: A Review and a Comparative Analysis with Other Immunohistochemical Markers

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