Cytomegaly of the Adrenal Gland

Cytomegaly of the Foetal Adrenal Cortex

“…Several investigations have demonstrated an increased frequency of cytomegaly among infants with malformations (4,13,25,28) In our material there were nine cases of malformations. Three of these had omphalocele, and on?…”

“…In five cases the maternal urinary oestriol excretion was determined. In three cases the terminal value was below the normal range, an increased frequency of cytomcgaly in cases of erythroblastosis (2,3,4,10,12,25). We found six cases of cytornegaly among 40 infants with erythroblastosis.…”

“…The occurrence of large atypical cells in the foetal adrenals from human foetuses and newborn infants was first described by Craig & Landing in 1951, and later in several greater materials of otherwise normal adrenals in this age group (3,4,7,13,25,29).…”

Cytomegaly of the Foetal Adrenal Cortex

“…Several investigations have demonstrated an increased frequency of cytomegaly among infants with malformations (4,13,25,28) In our material there were nine cases of malformations. Three of these had omphalocele, and on?…”

“…In five cases the maternal urinary oestriol excretion was determined. In three cases the terminal value was below the normal range, an increased frequency of cytomcgaly in cases of erythroblastosis (2,3,4,10,12,25). We found six cases of cytornegaly among 40 infants with erythroblastosis.…”

“…The occurrence of large atypical cells in the foetal adrenals from human foetuses and newborn infants was first described by Craig & Landing in 1951, and later in several greater materials of otherwise normal adrenals in this age group (3,4,7,13,25,29).…”

Beckwith Weidemann Syndrome

“…An association between adrenal cytomegaly, hemihypertrophy, macroglossia, omphalocoele and pancreatic islet hyperplasia was described by Beatty and Hawes in 1955 [1]. However, it was first recognised as a syndrome complex by Beckwith in 1963 and Weidemann an year later, who recognised its familial nature as also the association with hypoglycaemia and macrosomia [2].…”

Macroglossia, abnormal umbilicus and hypoglycaemia (Beckwith’s syndrome)

“…The commonest associated disease in their experience was erythroblastosis foetalis. Cytomegaly of the adrenal cortex has also been reported in association with adrenal carcinoma (Sherman, Bass & Fetterman, 1958), congenital adrenal hypoplasia (Kerenyi, 1961), and with various other congenital abnormalities (Beatty & Hawes, 1955). The pink staining of the skin and internal organs was due to mercurochrome, some of which must have been absorbed through the exomphalos.…”

Cytomegaly of the Foetal Adrenal Cortex

“…Several investigations have demonstrated an increased frequency of cytomegaly among infants with malformations (4,13,25,28) In our material there were nine cases of malformations. Three of these had omphalocele, and on?…”

“…In five cases the maternal urinary oestriol excretion was determined. In three cases the terminal value was below the normal range, an increased frequency of cytomcgaly in cases of erythroblastosis (2,3,4,10,12,25). We found six cases of cytornegaly among 40 infants with erythroblastosis.…”

“…The occurrence of large atypical cells in the foetal adrenals from human foetuses and newborn infants was first described by Craig & Landing in 1951, and later in several greater materials of otherwise normal adrenals in this age group (3,4,7,13,25,29).…”

Beckwith Weidemann Syndrome

“…An association between adrenal cytomegaly, hemihypertrophy, macroglossia, omphalocoele and pancreatic islet hyperplasia was described by Beatty and Hawes in 1955 [1]. However, it was first recognised as a syndrome complex by Beckwith in 1963 and Weidemann an year later, who recognised its familial nature as also the association with hypoglycaemia and macrosomia [2].…”

Macroglossia, abnormal umbilicus and hypoglycaemia (Beckwith’s syndrome)

“…The commonest associated disease in their experience was erythroblastosis foetalis. Cytomegaly of the adrenal cortex has also been reported in association with adrenal carcinoma (Sherman, Bass & Fetterman, 1958), congenital adrenal hypoplasia (Kerenyi, 1961), and with various other congenital abnormalities (Beatty & Hawes, 1955). The pink staining of the skin and internal organs was due to mercurochrome, some of which must have been absorbed through the exomphalos.…”

Cytomegaly of the Foetal Adrenal Cortex

“…Several investigations have demonstrated an increased frequency of cytomegaly among infants with malformations (4,13,25,28) In our material there were nine cases of malformations. Three of these had omphalocele, and on?…”

“…In five cases the maternal urinary oestriol excretion was determined. In three cases the terminal value was below the normal range, an increased frequency of cytomcgaly in cases of erythroblastosis (2,3,4,10,12,25). We found six cases of cytornegaly among 40 infants with erythroblastosis.…”

“…The occurrence of large atypical cells in the foetal adrenals from human foetuses and newborn infants was first described by Craig & Landing in 1951, and later in several greater materials of otherwise normal adrenals in this age group (3,4,7,13,25,29).…”

Beckwith Weidemann Syndrome

“…An association between adrenal cytomegaly, hemihypertrophy, macroglossia, omphalocoele and pancreatic islet hyperplasia was described by Beatty and Hawes in 1955 [1]. However, it was first recognised as a syndrome complex by Beckwith in 1963 and Weidemann an year later, who recognised its familial nature as also the association with hypoglycaemia and macrosomia [2].…”

Macroglossia, abnormal umbilicus and hypoglycaemia (Beckwith’s syndrome)

“…The commonest associated disease in their experience was erythroblastosis foetalis. Cytomegaly of the adrenal cortex has also been reported in association with adrenal carcinoma (Sherman, Bass & Fetterman, 1958), congenital adrenal hypoplasia (Kerenyi, 1961), and with various other congenital abnormalities (Beatty & Hawes, 1955). The pink staining of the skin and internal organs was due to mercurochrome, some of which must have been absorbed through the exomphalos.…”