Cytomegalovirus is predictably present in perineal ulcers from immunosuppressed patients

Characteristics of cutaneous cytomegalovirus infection in non-acquired immune deficiency syndrome, immunocompromised patients

“…The previous study of patients with AIDS revealed similar results. 13 According to Resnick et al 22 the characteristic owl's eye inclusions were limited to the fully developed changes and they are not found during the early stage of infection. Thus, pathologists should be aware that a variety of histopathological findings correspond to each stage of infection.…”

“…[3][4][5][6][7][8][9][10] However, most cutaneous CMV lesions are associated with herpes simplex virus (HSV) infection and CMV isn't thought to play a significant pathogenetic role in patients with AIDS. [11][12][13][14][15] Cutaneous CMV disease in non-AIDS, immunocompromised patients, such as organ transplant hosts or leukaemia patients, is even rarer. Sporadic cases have been reported, but any access to large numbers of patients for conducting a controlled study has been limited due to the malady's extreme rarity.…”

A review of antiviral therapies in the treatment of cytomegalovirus

“…A rubelliform rash may accompany the mononucleosis-like presentation of CMV infection, particularly after treatment with ampicillin. In im-munocompromised patients, cutaneous CMV often presents in ulcerated lesions, commonly on the genitalia, perineum, and thighs (4)(5)(6)(7)(8)(9). Infection may produce a generalized eruption that is papular or purpuric (10).…”

Cytomegalovirus (CMV) and Helicobacter pylori(HP) found in oral mucosal ulcers

“…The diagnosis of CMV can also be made by in situ hybridization (10). Following the primary infection (subclinical in most cases) (11), CMV remains in a latent form which can reactivate or even transform the host cell to a malignant state (12). It has been shown that monocytes are a major site of persistence of CMV in peripheral blood mononuclear cells (13).…”