Cytomegalovirus Infection Complicating Renal Transplantation and Its Relationship to Acute Transplant Glomerulopathy

Boyce, Neil; Hayes, Kathleen; Gee, David L.; Holdsworth, S R; Thomson, Napier M.; Scott, D F; Atkins, Robert C.

doi:10.1097/00007890-198804000-00008

Cited by 59 publications

(23 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…CMV disease is also associated with post-transplant lymphoproliferative disorder (PTLD), transplant renal artery stenosis, post-transplant diabetes mellitus irrespective of immunosuppressive drugs, and recurrent thrombotic microangiopathy after kidney transplant (17)(18)(19). In renal transplant recipients, Richardson et al in 1981 posited that systemic CMV infection was linked to glomerulopathy characterized by enlargement or necrosis of endothelial cells and accumulation of mononuclear cells and fibrillar material in glomerular capillaries; however, this finding has subsequently been questioned (20,21).…”

Section: Cytomegalovirus Infectionmentioning

confidence: 99%

Common Infections in Kidney Transplant Recipients

Karuthu¹,

Blumberg

2012

Clinical Journal of the American Society of Nephrology

214

148

View full text Add to dashboard Cite

SummaryInfections are a major cause of morbidity and mortality in kidney transplant recipients. To some extent, these may be preventable. Careful pretransplant screening, immunization, and post-transplant prophylactic antimicrobials may all reduce the risk for post-transplant infection. However, because transplant recipients may not manifest typical signs and symptoms of infection, diagnoses may be confounded. Furthermore, treatment regimens may be complicated by drug interactions and the need to maintain immunosuppression to avoid allograft rejection. This article reviews common post-transplant infections, including prophylactic, diagnostic, and treatment strategies, providing guidance regarding care of kidney transplant patients with infection.

show abstract

Section: Cytomegalovirus Infectionmentioning

confidence: 99%

Common Infections in Kidney Transplant Recipients

Karuthu¹,

Blumberg

2012

Clinical Journal of the American Society of Nephrology

214

148

View full text Add to dashboard Cite

show abstract

“…The existence of this condition has been disputed by Herrera et al [44] and Boyce et al [45], who consider it to be a form of (vascular-type or 'transplant glomerulopathy') rejection.…”

Section: Symptomatologymentioning

confidence: 99%

“…CMV also infects endothelial cells of transplanted patients; these cells may even detach from the vessel wall and subsequently be released in the circulation [54]. In the mononuclear cell fraction of peripheral blood of a patient with a CMV infection after heart transplantation, Grefte et al [54] unexpectedly found distinctly large cells (35)(36)(37)(38)(39)(40)(41)(42)(43)(44)(45) Ìm diameter), reminiscent of the classical 'cytomegalic inclusion body cells'. In a subsequent study, Grefte et al [55] showed that those cells could be demonstrated in a substantial part of patients with an active CMV infection after solid-organ transplantation, especially in those with a high viral load in their blood.…”

Section: Pathophysiology Of CMV Infectionmentioning

confidence: 99%

Overcoming the Problem of Cytomegalovirus Infection after Organ Transplantation: Calling for Heracles?

Son¹,

Maar²,

Bij³

et al. 1999

Intervirology

View full text Add to dashboard Cite

Although diagnosis of CMV infections and treatment of CMV disease with effetive antiviral drugs have become much easier, the persistent problem of CMV infection after solid-organ transplantation still requires solid knowledge of the pathophysiology of its clinical manifestations in order to minimize the impact of CMV infections in the future. The complex symptomatology of CMV infection after solid-organ transplantation is reviewed as well as some of the new theories attempting to explain the myriad of symptoms seen after transplantation.

show abstract

“…or obli terative bronchiolitis in heart-lung recipients (36,37). The kidney is not usually a site of CMV disease; however, there is specu lation that CMV is sometimes involved in acute transplant glomerulopathy in renal transplant recipients (38). In bone marrow transplant recipients, CMV infection is associated with graft-versus-host disease (12.39) and graft-versus-leukemia effects (40), although which is cause and which is effect is not clear.…”

Section: Pathogenicity Of CMV At Different Body Sitesmentioning

confidence: 99%

Cytomegalovirus Pathogenesis in Transplantation

Grundy¹

1993

Canadian Journal of Infectious Diseases and Medical Microbiolog

View full text Add to dashboard Cite

JE GRUNDY. Cytomegalovirus pathogenesis in transplantation. Can J Infect Dis 1993;4(Suppl C):11C-17C. Cytomegalovirus (CMV) infection is an important cause of morbidity and mortality in the immunocompromised ; however. even within this group of patients, infection with CMV is not synonymous with disease. A number of factors affect the pathogenicity of U1e virus. An understanding of the mechanisms by which CMV causes disease at different sites in lhe body, and of how U1at might vary with different patient groups. is essential to the design of stategies for the prevention and treatment of disease. This review discusses the factors which affect the occurrence and type of CMV disease in different patient populations, and considers some of the underlying mechanisms which might contribute to pathology.

show abstract

Cytomegalovirus Infection Complicating Renal Transplantation and Its Relationship to Acute Transplant Glomerulopathy

Cited by 59 publications

References 0 publications

Common Infections in Kidney Transplant Recipients

Common Infections in Kidney Transplant Recipients

Overcoming the Problem of Cytomegalovirus Infection after Organ Transplantation: Calling for Heracles?

Cytomegalovirus Pathogenesis in Transplantation

Contact Info

Product

Resources

About