1995
DOI: 10.1002/bies.950171012
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Abstract: Finding that an avian herpesvirus can cause atherosclerosis in chickens prompted studies of human herpesviruses in human atherosclerosis. Antigens and nucleic acid sequences of cytomegalovirus (CMV), a widespread member of the herpesvirus family, were found in arterial lesions in human atherosclerosis, but infectious virus has not been observed. In atherosclerosis patients, high levels of CMV antibodies are present, suggesting the presence of virus that had been activated from a latent state. Atherosclerosis a… Show more

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Cited by 116 publications
(101 citation statements)
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References 21 publications
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“…Once the damage occurs, cholesterol accumulation will be accelerated and atherosclerosis becomes more prominent (Ross, 1993). This observation is consistent with the hypothesis that many risk factors, such as hypercholesterolemia, may contribute to the acceleration of the atherosclerotic process once a lesion in the blood vessel is induced by a viral infection (Melnick et al, 1995).…”
Section: Discussionsupporting
confidence: 83%
See 1 more Smart Citation
“…Once the damage occurs, cholesterol accumulation will be accelerated and atherosclerosis becomes more prominent (Ross, 1993). This observation is consistent with the hypothesis that many risk factors, such as hypercholesterolemia, may contribute to the acceleration of the atherosclerotic process once a lesion in the blood vessel is induced by a viral infection (Melnick et al, 1995).…”
Section: Discussionsupporting
confidence: 83%
“…The resultant up-regulation of expression and secretion of cytokines and growth factors associated with the activated leukocytes may provoke migration and proliferation of smooth muscle cells and other relative and reparative processes leading to lipid deposition and ultimately atherosclerosis (Campbell and Campbell, 1994;Massy and Keane, 1996). A role for herpesviruses, such as cytomegalovirus (CMV), in atherosclerosis has been suggested in studies with different approaches (Melnick et al, 1993;Nicholson and Hajjar, 1998). Antigens and nucleic acids of CMV have been demonstrated in the smooth muscle cells of carotid artery plaques (Melnick et al, 1983;Petrie et al, 1987).…”
mentioning
confidence: 99%
“…In contrast to other herpesviruses, such as HSV, which persists in neurones, and Epstein-Barr virus, which persists in B lymphocytes, the site of latency for CMV has not been identified definitively. 49 Many studies indicate both smooth muscle cells and leukocytes to be likely candidates. 50 In a classic study using immunofluorescence, Melnick et al 51 showed that more than 25% of the cell cultures from carotid artery plaques or uninvolved areas of aorta contained antigens of human CMV, but not HSV-1 or -2.…”
Section: Infectionsmentioning
confidence: 99%
“…Animal/experimental, pathological, and cross-sectional seroepidemiological studies conducted among middle-aged populations provide some support for the hypothesis that infections with herpes simplex virus type 1 (HSV-1), cytomegalovirus (CMV), and C pneumoniae are associated with the development of atherosclerosis and CHD. [5][6][7][8][9][10][11][12][13][14][15][16] However, recent reports from several prospective studies failed to demonstrate consistent associations between the presence of IgG antibodies to C pneumoniae, HSV-1, and CMV and incident MI. [17][18][19][20][21][22] Given both the high prevalence of IgG antibodies to these agents and the high incidence of cardiovascular disease among older adults, it is particularly important to determine whether serological evidence of prior infection with these agents, assessed late in life, is associated with incident MI and CHD death.…”
Section: T He Role Of Viruses and Other Infectious Agents Such Asmentioning
confidence: 99%