1981
DOI: 10.1001/archderm.117.5.282
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Cytomegalic inclusion disease of the skin

Abstract: Acute cytomegalovirus infection was associated with two episodes of morbilliform eruption in a patient receiving ampicillin therapy. Shortly after the eruption cleared, the patient died. Histologic examination of the skin indicated a cytomegalovirus infection of the vascular endothelium with luminal obliteration, stasis, vasculitis, and thrombus formation.

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Cited by 17 publications
(11 citation statements)
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“…ampicillin [4, 17]. They include generalized macular and papular rashes, urticarial and scarlatiniform eruptions [11, 18].…”
Section: And Skin Lesionsmentioning
confidence: 99%
“…ampicillin [4, 17]. They include generalized macular and papular rashes, urticarial and scarlatiniform eruptions [11, 18].…”
Section: And Skin Lesionsmentioning
confidence: 99%
“…Specific sites of latency, as well as mechanisms of reactivation also remain elusive [33]. In response to these uncertainties evidence continues to accumulate implicating the endothelial cell as a common target of infection regardless of the organ involved [1,9,12,19,22,25,34,39,49,62,65]. These findings suggest that this cell type may be an important mediator in the pathogenesis of human CMV disease [36].…”
Section: Introductionmentioning
confidence: 99%
“…Although pulmonary infection is most common [Myerson et al, 19841, the virus manifests itself in nearly all organs. Careful studies have indicated that the endothelial cell is a common site of infection regardless of the organ involved [Vogel, 1958;Craighead, 1971;Goodman and Porter, 1973;Augsberger and Henry, 1978;Foucar et al, 1981;Lin et al, 1981;Myerson et al, 1984;Hinnant et al, 1986;Hashimoto et al, 1987;Roberts et al, 1989. In vitro studies of CMVJendothelial cell interactions have yielded varying results. Friedman et al [19811 reported a failure to infect endothelial cells (both bovine and human) with the Davis strain of CMV, as determined by the absence of cytopathic changes or CMV nuclear antigens in inoculated cells, as well as by the absence of detectable levels of infectious virus in the corresponding culture supernatants.…”
Section: Introductionmentioning
confidence: 99%