Cytological Demonstration of the Clonal Nature of Spleen Colonies Derived from Transplanted Mouse Marrow Cells

Becker, Andrew; McCulloch, E. A.; Till, J. E.

doi:10.1038/197452a0

Cited by 1,260 publications

(564 citation statements)

References 8 publications

Supporting

Mentioning

521

Contrasting

Unclassified

Order By: Relevance

“…Soon after, Till and McCulloch (1961) provided evidence that single multipotent hematopoietic progenitor cells (cells giving rise to more than one lineage of blood cells) could be identified in vivo by injecting donor marrow cells into a lethally irradiated recipient animal and examining the recipient spleen for hematopoietic colonies 8 -12 days later. Each colony of hematopoietic cells in the spleen was demonstrated to arise from a single precursor cell, the colonyforming unit in spleen cell (CFU-S) (Becker et al, 1963). Use of this assay provided the first compelling evidence that hematopoietic cells were clonally derived.…”

Section: Methods Of Identifying Hematopoietic Stem and Progenitor Cellsmentioning

confidence: 99%

Blood cell progenitors: Insights into the properties of stem cells

Yöder

2003

Anat. Rec.

View full text Add to dashboard Cite

Hematopoiesis is a dynamic process in which eight lineages of mature blood cells are derived from a common stem cell. Great progress has been made in identifying the functionally disparate progenitors that emerge from the stem cell and in elucidating the molecules required for their growth and survival. Further work will be required to understand the molecular mechanisms that regulate commitment of stem and progenitor cells to each stage of progenitor cell development and ultimately into the mature blood cells. Anat Rec Part A 276A: 66 -74, 2004.

show abstract

Section: Methods Of Identifying Hematopoietic Stem and Progenitor Cellsmentioning

confidence: 99%

Blood cell progenitors: Insights into the properties of stem cells

Yöder

2003

Anat. Rec.

View full text Add to dashboard Cite

show abstract

“…Stem cells were first studied by Becker et al (1963), who injected bone marrow cells into irradiated mice and noticed that nodules developed in the spleens of the mice in proportion to the number of bone marrow cells injected. They concluded that each nodule arose from a single marrow cell.…”

Section: Stem Cellsmentioning

confidence: 99%

Updates on stem cells and their applications in regenerative medicine

Bajada

Mazakova

Richardson

et al. 2008

J Tissue Eng Regen Med

305

188

View full text Add to dashboard Cite

“…The first adult stem cells were discovered almost 50 years ago. Researches discovered that bone marrow contained two different populations of stem cells; hematopoietic stem cells (HSCs) [41,42] and bone marrow stromal cells [43]. The HSC give rise to all red and white blood cells and also platelets.…”

Section: Adult Stem Cellsmentioning

confidence: 99%