Cytologic Features of Hepatoid Carcinoma of the Ovary

Metastatic hepatocellular carcinoma in the maxilla and mandible, an extremely rare presentation

“…It can mimic adenocarcinoma with a pseudo-glandular pattern or may be poorly differentiated, causing difficulty in detecting the cells of origin. [ 17 ] Hence, immunohistochemical (IHC) markers are used for diagnosis. Glypican-3, HepPar1, CD34 are the markers that can be used to confirm the microscopic diagnosis of HCC.…”

A case report of Hepatoid Carcinoma of the Ovary with peritoneal metastases treated with cytoreductive surgery and hyperthermic intraoperative intraperitoneal chemotherapy without systemic adjuvant therapy

“…Metastatic disease most commonly manifests as peritoneal seeding and intraabdominal visceral metastasis and less frequently as distant hematogenous spread. In addition to the current report, one case was managed surgically with CRS plus HIPEC using paclitaxel as an intraoperative agent [26]. The patient achieved a complete cytoreduction (CC = 0), and was further treated with adjuvant chemotherapy consisting of paclitaxel and carboplatin.…”

“…HCO is considered a rare entity with 33 cases documented since Ishikura and Scully’s report [4], [6], [8], [11], [12], [13], [14], [15], [16], [17], [18], [19], [20], [21], [22], [23], [24], [25], [26], [27], [28], [29], [30], [31], [32], [33], described in both pre- and post-menopausal females between 35 and 78 years old. The vast majority of patients are found to have advanced disease (stage III/IV) at the time of diagnosis.…”

SALL4 as an indicator for the diagnosis of hepatoid carcinoma of the ovary: A case report and literature review

“…In 1987, Ishikura and Scully first reported five cases of HCO, mainly in postmenopausal women who presented with an ovarian mass and elevated serum AFP 2 . The microscopic characteristics of these tumors are sheets, trabeculae, and cords of cells with moderate‐to‐large amounts of eosinophilic cytoplasm and round to oval central nuclei 3 . HCO must be distinguished from the HCC metastatic to the ovary 4 and other ovarian tumors with abundant eosinophilic cytoplasm, including hepatoid yolk sac tumors (HYSTs), 5 Sertoli–Leydig cell tumors, and oxyphilic clear cell carcinomas.…”

“… 2 The microscopic characteristics of these tumors are sheets, trabeculae, and cords of cells with moderate‐to‐large amounts of eosinophilic cytoplasm and round to oval central nuclei. 3 HCO must be distinguished from the HCC metastatic to the ovary 4 and other ovarian tumors with abundant eosinophilic cytoplasm, including hepatoid yolk sac tumors (HYSTs), 5 Sertoli–Leydig cell tumors, and oxyphilic clear cell carcinomas. We describe an additional case of a 64‐year‐old postmenopausal Chinese woman diagnosed with HCO, featuring with significantly elevated serum AFP and CA125 levels.…”