2014
DOI: 10.1016/j.biocel.2013.11.015
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Abstract: Although there is a growing literature describing the role of macrophages in breast cancer, the role of macrophages in inflammatory breast cancer (IBC) is unclear. The aim of present study was to isolate and characterize tumor associated macrophages of IBC and non-IBC patients and define their role in IBC. Tumor infiltrating monocytes/macrophages (CD14+ and CD68+) were measured by immunohistochem-istry using specific monoclonal antibodies. Blood drained from axillary vein tributaries was collected during breas… Show more

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Cited by 77 publications
(85 citation statements)
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“…These molecules modulate growth, proliferative, migration, and apoptotic pathways, often resulting in metastasis and advanced stage disease (33)(34)(35)(36)(37)(38)(39)(40). Next, we evaluated expression of a panel of cytokines associated with disease progression using pancreas tumor tissues from the same cohort in the previous section by qPCR.…”
Section: Resultsmentioning
confidence: 99%
“…These molecules modulate growth, proliferative, migration, and apoptotic pathways, often resulting in metastasis and advanced stage disease (33)(34)(35)(36)(37)(38)(39)(40). Next, we evaluated expression of a panel of cytokines associated with disease progression using pancreas tumor tissues from the same cohort in the previous section by qPCR.…”
Section: Resultsmentioning
confidence: 99%
“…Association between the CRP/ALB ratio and NLR with clinicopathological characteristics in patients with gastric cancer. of transcription 3 and nuclear factor κB, and recruit an increased number of inflammatory cells, including neutrophilic granulocytes and mononuclear macrophages, to the lesion site and thereby assist in forming an inflammatory microenvironment (13,30,31). The interaction between tumor cells and inflammatory factors may suppress the immunosurveillance of T and natural killer cells (32), enhance the permeability of blood and lymphatic vessels and degrade the extracellular matrix, thereby potentiating tumor development and metastasis (12,33).…”
Section: Discussionmentioning
confidence: 99%
“…14,19,29,31,34,78,[80][81][82][83][84][85][86] We propose that the elevated OSM expression levels observed in cancerous tissues is an extension of the inflammatory environment initially created during the early stages of transformation as a means to suppress tumorigenicity. There is mounting evidence that OSM in the TME contributes to tumor progression.…”
Section: Discussionmentioning
confidence: 99%