Cytokines and Pain

Oliveira, Clair Motos de; Sakata, Rioko Kimiko; Issy, Adriana Machado; Gerola, Luís Roberto; Salomão, Reynaldo

doi:10.1016/s0034-7094(11)70029-0

Cited by 147 publications

(95 citation statements)

References 35 publications

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“…High NO levels can be cytotoxic [Marcus et al, 2003]. Cytokines cause glial cell hypertrophy and prolif- eration, and release related proinflammatory cytokines, e.g., IL-1β, TNF-α, and IL-6, forming a network of autonomous activation [De Oliviera et al, 2011]. Recently, Zhu et al [2016] observed increased levels of cytokines and GFAP in the hippocampus of rats showing tibial fractures; this inflammatory cascade leads to postoperative neuroinflammation.…”

Section: Discussionmentioning

confidence: 99%

Reactive Astrogliosis in an Experimental Model of Fibromyalgia: Effect of Dexmedetomidine

Abd-ellatief

Mohamed

Kotb

2018

Cells Tissues Organs

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To our knowledge, this is the first study which investigates the induction of neuroinflammation in rats using an acidic-saline model of fibromyalgia. It is well known that the hippocampus has a fundamental role in pain perception, and astrocytes play a crucial role in pain signaling. Our aim is to evaluate the ability of dexmedetomidine to attenuate the inflammatory responses induced in astrocytes. In a group of healthy rats, induction of chronic muscle pain by intramuscular injection of 100 µL of acidic saline on days 0 and 5 resulted in peripheral sensitization (measured using the von Frey test) and significant (p < 0.05) increases in IL-1β (160.2 ± 1.1 to 335.2 ± 1.8), IL-6 (100.1 ± 1.4 to 202.4 ± 1.1), and TNF-α (60.0 ± 0.7 to 115.5 ± 1). Light and electron microscopy revealed degenerative changes in the hippocampus and reactive astrogliosis. Immunohistochemistry showed increased expression of glial fibrillary acid protein and inducible nitric oxide synthase. Surprisingly, treatment with a single dose of an α₂-adrenergic agonist, dexmedetomidine (5 µg/kg i.p.), attenuated these changes. This trial suggests that dexmedetomidine possibly directly acts on astrocytes, and a peripheral action is also suggested.

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Section: Discussionmentioning

confidence: 99%

Reactive Astrogliosis in an Experimental Model of Fibromyalgia: Effect of Dexmedetomidine

Abd-ellatief

Mohamed

Kotb

2018

Cells Tissues Organs

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“…Moreover, NGF acts through posttranscriptional regulation of receptors and ion channels inducing mechanical and thermal hyperalgesia. 25 In summary, there are several positive During inflammation, several mediators directly or indirectly induce pain including pro-inflammatory cytokines and there is evidence that the JAK-STAT pathway is involved in the formation of pronociceptive cytokines. The same pathway, however, is also of importance for anti-inflammatory cytokines such as iL-4 to counteract the inflammatory reaction and-as it seems based on the current literature-nociceptive symptoms.…”

Section: Pain and Inflammationmentioning

confidence: 99%

IL-4, JAK-STAT signaling, and pain

Busch-Dienstfertig

González-Rodríguez

2013

JAK-STAT

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“…However, extent of surgical resection was not significantly associated with reduction of inflammation. It is also possible that physical discomfort and or pain associated with the tumor mass and/or ascites may have affected inflammatory pathways and functional outcome measures independently (De Jongh et al 2006;de Oliveira, Sakata, Issy, Gerola, & Salomão 2011). Because the current study does not include substantive measures of pain we were unable to examine the relationship of pain with variables of interest.…”

Section: Discussionmentioning

confidence: 89%

138. Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: Relationships with depression, fatigue, and disability

Schrepf

Clevenger

Christensen

et al. 2012

Brain, Behavior, and Immunity

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Elevations in the pro-inflammatory cytokine interleukin-6 (IL-6) and alterations in the antiinflammatory hormone cortisol have been reported in a variety of cancers. IL-6 has prognostic significance in ovarian cancer and cortisol has been associated with fatigue, disability, and vegetative depression in ovarian cancer patients prior to surgery. Ovarian cancer patients © 2012 Elsevier Inc. All rights reserved.Corresponding Author: Susan K. Lutgendorf, Ph.D. Department of Psychology University of Iowa E11 Seashore Hall Iowa City IA 52242 PH: 319-335-2432 FX: 319-335-0191 susan-lutgendorf@uiowa.edu. Publisher's Disclaimer: This is a PDF file of an unedited manuscript that has been accepted for publication. As a service to our customers we are providing this early version of the manuscript. The manuscript will undergo copyediting, typesetting, and review of the resulting proof before it is published in its final citable form. Please note that during the production process errors may be discovered which could affect the content, and all legal disclaimers that apply to the journal pertain. NIH Public AccessAuthor Manuscript Brain Behav Immun. Author manuscript; available in PMC 2014 March 01. NIH-PA Author ManuscriptNIH-PA Author Manuscript NIH-PA Author Manuscript undergoing primary treatment completed psychological self-report measures and collected salivary cortisol and plasma IL-6 prior to surgery, at six months, and at one year. Patients included in this study had completed chemotherapy and had no evidence of disease recurrence. At six months, patients showed significant reductions in nocturnal cortisol secretion, plasma IL-6, and a more normalized diurnal cortisol rhythm, changes that were maintained at one year. The reductions in IL-6 and nocturnal cortisol were associated with declines in self-reported fatigue, vegetative depression, and disability. These findings suggest that primary treatment for ovarian cancer reduces the inflammatory response. Moreover, patients who have not developed recurrent disease by one year appear to maintain more normalized levels of cortisol and IL-6. Improvement in fatigue and vegetative depression is associated with the normalization of IL-6 and cortisol, a pattern which may be relevant for improvements in overall quality of life for ovarian cancer patients.

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Cytokines and Pain

Abstract: Cytokines have an important role in pain through different mechanisms in several sites of pain transmission pathways.

Cited by 147 publications

References 35 publications

Reactive Astrogliosis in an Experimental Model of Fibromyalgia: Effect of Dexmedetomidine

Reactive Astrogliosis in an Experimental Model of Fibromyalgia: Effect of Dexmedetomidine

IL-4, JAK-STAT signaling, and pain

138. Cortisol and inflammatory processes in ovarian cancer patients following primary treatment: Relationships with depression, fatigue, and disability

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